Ilias Biologics Inc.

Ilias Therapeutics, Inc.

Seung-Wook Ryu

Chulhee Choi

Kyungsun Choi

Hojun Choi

Nambin Yim

Won Do Heo

The present invention provides a method for producing an exosome that transfers an active substance specifically to a target and the exosome produced by the same; a method for delivering the active substance to the target tissue using the exosome; a pharmaceutical composition for delivery of the active substance comprising the exosome as an active ingredient; and a composition for preparing the exosome comprising an expression vector wherein the target peptide is inserted into an extracellular portion of a transmembrane protein.

Exosomes for target specific delivery and methods for preparing and delivering the same

The present invention relates to a method for the mass-production of exosome comprising a cargo protein, a vector for preparing the exosome, exosome including a cargo protein prepared by the method, and a method for loading the cargo protein to cytosol by using the exosome prepared thereby. According to the method for preparing an exosome comprising a cargo protein provided by the present invention, the exosome loaded with a cargo protein can be produced with a high yield, so that it can be used broadly in the treatment of disease using the exosome.

Compositions containing protein loaded exosome and methods for preparing and delivering the same

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Daejeon, South Korea

Seung-Wook Ryu