Samyang Genex Corporation

Samyang Genex Co.

Other

Korea Advanced Institute of Science and Technology

Seung-Suh Hong

Hyun-soo Lee

Jin-Hyun Kim

Sun-Chang Kim

Bong-Kyu Song

Jeong-Hwan Yun

Sang-Ic Kim

Hyung-Kyoon Choi

Ho-Joon Choi

Roy William Stahlhut

Jun-Seog Song

Tom Lee Adams

Bok Luel Lee

Neon-Cheol Jung

Chong Jin Park

Hyun-Soo Lee

Chan-Bae Park

Sang-Hyun Pyo

Jae Hyun Lee

Min Hyung Kang

Jeong Hyun Kim

Bu Soo Park

Insoo Bae

Chang Hun Joo

Joo-Sun Son

Yong-Weon Yi

Gwang-Hwee Na

Eunsoo Choi

In-Cheol Kim

Kwang-Wook Kim

Chang-Bae Lim

Hong-Rak Kim

In-Seon Kang

Dong-soo Kim

Heajoon Yim

Hyun-Geun Yoon

Moon-Seok Chang

Choong-Kyung Kang

Jin-Man Kim

Hung-Bok Park

Dong-Kyun Lee

Young-Rim Seong

Jae-Ho Lee

Kum Young Lee

Jin-Eon So

Jae-Hyun Lee

Joong Hyuck Auh

Heung-Bok Park

Mi Young Cho

The present invention relates to a composition for detecting an infinitesimal quantity of &#x3b2;-1,3-glucan, a preparation method thereof and a diagnostic kit detecting &#x3b2;-1,3-glucan. The composition of the present invention shows phenoloxidase activity by &#x3b2;-1,3-glucan in the presence of calcium ions. Using the composition of the present invention, a sample is gathered from a specimen, the composition of the present invention and calcium ions are added to the sample, and &#x3b2;-1,3-glucan is detected by measuring phenoloxidase activity.

Composition for detecting &#x3b2;-1,3-glucan

The present invention relates to a method of removing an endotoxin from solution containing basic proteins. More specifically, the method of the present invention comprises the steps of adding the surfactant to solution containing the basic protein obtained from the recombinant microorganism and mixing the resultant, of loading the resultant solution on the cation exchange column, washing the cation exchange column with solution which does not contain surfactant, and eluting the basic protein of interest from the cation exchange column.

Method for removing endotoxin from the samples containing basic protein

The present invention relate to a method to increase the production level of paclitaxel by changing the temperature during the plant cell culture. According to the present invention, the production of the paclitaxel comprises the following procedure: (i) cultivating the Taxus genus plant cells in a medium at ca. 20 to 25&deg; C.; and (ii) when growth of the plant cells has progressed sufficiently, changing the cultivation temperature to ca. 26 to 32&deg; C. to continue the culture. The present invention comprises also the method of increasing the paclitaxel production by inoculating the cells at a high initial concentration and by increasing the saccharide concentration in the medium: According to the present invention, paclitaxel can be mass-produced conveniently and therefore has an industrial application.

Mass production of paclitaxel by changing the temperature of the medium during the plant cell culture

The present invention relates to a diagnosis method of cancer using SYG972 gene and to the genomic DNA and to a promoter regulating transcription of the gene. Expression of SYG972 gene is greatly reduced in breast cancer cells compared to normal breast cells. Therefore the present invention provides a method of diagnosis method by using the gene of the present invention or its fragments as a probe. SYG972 genomic according to the present invention is composed of 4 exons and 3 introns. Promoter is 3 kb long from the transcription initiating site in the 5&prime; direction. SYG972 genomic DNA and promoter can be used to design and screen drugs to promote or to inhibit apoptosis and differentiation of cells, especially to screen drugs to treat cancer, a disease wherein cell growth and differentiation is abnormal.

Cell growth inhibiting and cell differentiation specific SYG972 gene, genomic DNA and promoter thereof

The present invention relates to peptides that are more potent than or equally potent as the conventional antimicrobial peptides and has strong antimicrobial activities at high salt concentration.

Peptides having biological activity

The present invention relates to a protein related to encapsulation in immune reaction and a gene encoding the same.

Proteins related to encapsulation and genes encoding the same

The present invention provides a method for mass production of taxol which comprises adding sugar into a culture medium containing sugar in the course of semicontinuous culture of Taxus genus plant cell, and a universal method for mass production of taxol which comprises culturing Taxus genus plant cell in a culture medium containing sugar and AgNO,as well. In accordance with the present invention, large amount of taxol can be produced with a high yield, simply by manipulating the culture condition of Taxus genus plant cell culture.

Production of taxol from taxus plant cell culture adding silver nitrate

The present invention relates to a novel use of histone and provides a pharmaceutical composition containing histone as an active ingredient to improve the symptoms of progressive, inflammatory and autoimmune arthritis. The pharmaceutical composition of the present invention includes histone, especially histone H1 as an active ingredient, and could include pharmacologically approved carriers if necessary. Histone H1 lowered induction of arthritis and reduced arthritis index more effectively than steroidal dexamethasone and also had a significant preventive effect.

Method for treating rheumatoid arthritis with composition containing histone

The present invention provides a method for mass production of an antimicrobial peptide, which comprises the steps of: constructing a fusion gene containing a first gene encoding a negatively charged acidic peptide having at least two cysteine residues and a second gene encoding a positively charged basic antimicrobial peptide; transforming a host microorganism with an expression vector comprising the fusion gene; cultivating the transformed microorganism to express a fusion peptide containing the acidic peptide and antimicrobial peptide, and, recovering the expressed antimicrobial peptide. In accordance with the present invention, the inhibitory effect of the expressed antimicrobial peptide on the growth of the host microorganism can be dramatically minimized by fusing it with the acidic peptide. Accordingly, antimicrobial peptides can be produced massively from a recombinant microorganism regardless of the kind of the antimicrobial peptides.

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Taejon, South Korea

Seung-Suh Hong