Jw Creagene Inc.

Seung-Soo Han

Yong-Soo Bae

Young-Mok Kim

Yoon Sung Lee

Yoon Young Lee

So-Yeon Kim

Hye-Won Kang

Seo-Hee Ahn

The present invention relates to a method for preparing a dendritic cell, a dendritic cell prepared thereby and a use thereof, and more specifically, to a method for preparing a dendritic cell, including: treating a dendritic cell at a maturation stage rather than at an immature stage with an antigen bound to a peptide having a cell membrane permeability to prepare a dendritic cell with improved antigen-presenting ability, a dendritic cell prepared by the method, and an immunotherapeutic agent thereof, a use for anti-tumor vaccines, or a pharmaceutical composition for treating tumors, containing the same.

Method for preparing dendritic cell, dendritic cell prepared thereby, and use thereof

The present invention relates to a composition for maturing dendritic cells, comprising, as a maturation-promoting factor, Interleukin-1&#x3b2; (IL-1&#x3b2;), Interleukin-6 (IL-6), Tumor necrosis factor-&#x3b1; (TNF-&#x3b1;), Interferon-&#x3b3; (IFN-&#x3b3;), Prostaglandin E2 (PGE2), Picibanil (OK432) and/or Poly IC. The composition for maturing dendritic cells of the present invention may have the effects of not only improving the ability of dendritic cells to induce an immune response, but also of decreasing the antigen non-specific immune response of dendritic cells and increasing antigen-specific immune response of dendritic cells, thus maximizing the effects of immunotherapy.

Composition for maturing dendritic cells, and method for preparing antigen-specific dendritic cells using same

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Gyeonggi-do, South Korea

Seung-Soo Han