Chong Kun Dang Pharmaceutical Corporation

Seung-Kee Moon

Young-Hoon Kim

Soon-Kil Ahn

Sung-Sook Lee

Soo-Jin Kim

Ho-Jin Choi

Jae-Kwang Lee

Nam-Song Choi

Jae-Hoon Choi

Hyun-Mo Yang

Sang-Yong Lee

Yeo-Wook Koh

Su-Yon Kim

Hee-Ryong Kang

Sun-Ju Kong

Young-Min Kwon

Jae-Su Shin

Hyun-Jung Yu

In-Taek Lim

Young-Mi Kim

Su-Yeal Bae

Kyung-Joo Lee

So-Ra Park

Dal-Hyun Kim

Byeong-Hoon Han

Gyu-Tae Park

Ki-Young An

The present invention relates to anti-ErbB2 antibody variants or antigen-binding fragments thereof, nucleic acid molecules encoding them, and their uses. The antibody variants of the present invention are capable of binding to ErbB2 with high affinity. Therefore, the antibody variants are ability to effectively prevent or treat various cancers with a low amount.

Anti-ErbB2 antibody variants

The present invention relates to an expression vector for animal cells, comprising: (a) CSP-B (Cytotoxic Serine Protease-B) 5'-SAR (Scaffold or Matrix Attachment Region); (b) a promoter operable in animal cells; and (c) a polyadenylation sequence, and to a method for producing recombinant proteins using same. The vector of the present invention includes CSP-B 5&#x2032;-SAR, and thus has the effect of overcoming the inhibition of gene expression according to the position of a foreign gene introduced into an animal cell, and significantly improving the expression rate of a target protein. The vector of the present invention effectively expresses recombinant proteins for drugs or antibodies in animal cells. The vector of the present invention and the method for producing recombinant proteins using same may be very usefully applied to the industrial mass production of drugs.

Expression vector for animal cells including CSP-B 5'-SAR factor and method for producing recombinant proteins using same

Disclosed are a novel thiazole-containing benzophenone derivative represented by formula 1, and an isomer thereof, a pharmaceutically acceptable salt thereof, a hydrate thereof and a solvate thereof, a pharmaceutical composition comprising the derivative, a use of the derivative as therapeutic agent and a method for preparing the derivative. The benzophenone thiazole derivatives inhibit formation of microtubules and eliminate actively proliferating cells of malignant tumors to control general cell proliferation. In formula 1, R, Rand Rare defined as above.

Benzophenone thiazole derivatives useful for inhibiting formation of microtubule and method for producing the same

Disclosed herein are novel benzophenone derivatives represented by formula I, a pharmaceutically acceptable salt thereof, a hydrate thereof or a solvate thereof, a pharmacological composition containing the same, and a use of the composition as therapeutic drugs. The benzophenone derivatives have an inhibition activity of microtubule formation and can be used to treat a normal proliferative state of a malignant tumor by killing the actively proliferating cells.

Benzophenone derivatives useful for inhibiting formation of microtubule

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Yongin-si, South Korea

Seung-Kee Moon