Korea Institute of Science and Technology

The Asan Foundation

Futurechem Co., Ltd

Seung-jun Oh

Jae-seung Kim

Jin-sook Ryu

Dae-hyuk Moon

Jong-Jin Lee

Chansoo Park

Laehyun Kim

Dae-Yoon Chi

Byoung-Se Lee

So-Young Chu

Da-Hye Kim

Sirion Uthaiwan

Yu-Jin Bae

Sang-ju Lee

Eon Jo Hong

The present disclosure relates to technology that controls a remote moving body based on collaboration between the moving body and human, and a method for controlling a moving body includes acquiring a first biosignal indicating an intention to start operation of the moving body from a user, operating the moving body, determining a surrounding situation of the moving body that autonomously controls the driving, providing the user with surrounding information of the moving body for inducing path setting, acquiring a second biosignal evoked by recognition of the surrounding information from the user, setting a driving direction of the moving body, commanding the moving body to automatically perform a driving operation to be carried out in the set driving direction, and acquiring a third biosignal responsive to recognition of a driving error from the user and correcting the driving direction of the moving body to induce driving path resetting.

Method for controlling moving body based on collaboration between the moving body and human, and apparatus for controlling the moving body thereof

A method for preparing a radiopharmaceutical and, specifically, a method for preparing an organic fluoride-aliphatic compound usable as a radiopharmaceutical, a method for purifying the prepared organic fluoride-aliphatic compound, and a method for preparing a radiopharmaceutical by using a cassette comprising a backdraft preventing reaction container. A method for preparing an organic fluorinated aliphatic compound includes allowing a fluorine salt to react with a leaving group-containing aliphatic compound by using a multifunctional solvent represented by the following Chemical Formula 1 to obtain an aliphatic compound labeled with [F] fluoride substituting for the leaving group. The organic fluoride-aliphatic compound can be prepared and purified through even a simple process at high yield, high efficiency, and high purity, and the radiopharmaceutical can be safely prepared without damage to a synthetic apparatus.

Method for preparing organic fluoride-aliphatic compound and method for purifying organic fluoride-aliphatic compound

The present invention relates to (3-fluoro-2-hydroxy)propyl-functionalized aryl derivatives or to the pharmaceutically acceptable salt thereof, to a method for preparing same, and to a pharmaceutical composition containing same as active ingredients for the diagnosis or treatment of neurodegenerative brain diseases. The aryl derivatives of the present invention are (3-fluoro-2-hydroxy)propyl-functionalized to increase the polarity thereof, and therefore the drugs containing the aryl derivatives can easily permeate into the cerebrovascular membrane, thus increasing the effectiveness of the drugs. As the aryl derivatives of the present invention strongly bind to &#x3b2;-amyloid, the aryl derivatives, when labeled with radioisotope, can be used as a diagnostic agent for non-invasively diagnosing early Alzheimer's disease. Further, the aryl derivatives of the present invention bind to low molecular &#x3b2;-amyloid peptide conjugates to inhibit the generation of malignant high molecular &#x3b2;-amyloid plaque, and thus can be effectively used as a therapeutic agent for neurodegenerative brain diseases such as Alzheimer's disease.

(3-fluoro-2-hydroxy)propyl-functionalized aryl derivatives or pharmaceutically acceptable salts thereof, method for preparing same, and pharmaceutical composition containing same as active ingredient for the diagnosis or treatment of neurodegenerative brain diseases

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Seoul, South Korea

Seung-jun Oh