Beam Therapeutics Inc.

Revolution Medicines, Inc.

Warp Drive Bio, Inc.

Seung-Joo Lee

Yi Yu

Bernd Zetsche

Ian Slaymaker

Nicole Marie Gaudelli

Michael S Packer

David A Born

Gregory Lawrence Verdine

Neville J Anthony

Sharon Ann Townson

Dylan Talbot Stiles

Uddhav Kumar Shigdel

M James Nichols

Jason Michael Gehrke

Francine Gregoire

Genesis Lung

Natalie Petrossian

Shaunna Berkovitch

Angelica Messana

Yvonne Aratyn

Nicole Gaudelli

The present invention features compositions and methods for editing deleterious mutations associated with hemoglobinopathies, such as sickle cell disease (SCD). In particular embodiments, the invention provides methods for correcting mutations in a beta globin polynucleotide using modified adenosine base editors termed 'ABE8' having unprecedented levels (e.g., >60-70%) of efficiency.

Compositions and methods for treating hemoglobinopathies

The present invention features compositions and methods for editing deleterious mutations associated with hemoglobinopathies, such as sickle cell disease (SCD). In particular embodiments, the invention provides methods for correcting mutations in a beta globin polynucleotide using modified adenosine base editors termed 'ABE8' having unprecedented levels (e.g., &#x3e;60-70%) of efficiency.

The disclosure provides compositions comprising novel adenosine base editors (e.g., ABE8) that have increased efficiency and methods of using these adenosine deaminase variants for editing a target sequence.

Adenosine deaminase base editors and methods of using same to modify a nucleobase in a target sequence

The present disclosure provides methods and reagents useful for analyzing protein-protein interfaces such as interfaces between a presenter protein (e.g., a member of the FKBP family, a member of the cyclophilin family, or PIN1) and a target protein. In some embodiments, the target and/or presenter proteins are intracellular proteins. In some embodiments, the target and/or presenter proteins are mammalian proteins.

Methods and reagents for analyzing protein-protein interfaces

Growing community of inventors

Cambridge, MA, United States of America

Seung-Joo Lee