The Asan Foundation

Korea Institute of Science and Technology

University of Ulsan Foundation for Industry Cooperation

Futurechem Co., Ltd

Edisbiotech Co., Ltd.

Seung-Jae Myung

Eun-Ju Do

Seung-Jin Lee

Ick-Chan Kwon

Hyori Kim

Kui-Won Choi

Dae-Yoon Chi

Kwang-Meyung Kim

Kyeong-Soon Park

Dae-hyuk Moon

In-Chan Youn

Seul-Ki Lee

Sang-Yeob Kim

Yeong Hui Cho

Hye-Nam Son

Dong-Jun Bae

A-Neum Lee

Sang Mun Bae

Jayoung Kang

The present invention relates to a monoclonal antibody which specifically binds to an EGF2 domain of colon cancer secreted protein-2 (CCSP-2), or an antigen-binding fragment thereof. The monoclonal antibody or the antigen-binding fragment thereof of the present invention specifically binds to the EGF2 domain of CCSP-2, and thus has significantly increased affinity compared with existing peptides specifically binding to CCSP-2 and further increased specificity compared with existing antibodies to CCSP-2. Therefore, in future, accurate diagnosis can be achieved by specific detection of CCSP-2 in the protein level.

Monoclonal antibody specifically binding to CCSP-2 and use thereof

There is disclosed a multi-wavelength endoscopic system for imaging an observation site labeled with a plurality of fluorescent materials having different colors. The system includes an imaging unit configured to acquire image data by polarizing incident light reflected from the observation site in a first direction and a second direction perpendicular to the first direction, dividing a spectrum region of the incident light polarized in the first direction and the second direction into a plurality of spectrum channels and measuring the intensity of light for each of the spectrum channel. The system further includes a computing unit configured to store a single fluorescence spectrum extracted from sample image data obtained by single-treating the observation site with each of the fluorescent materials and configured to separate and output the image data obtained in the imaging unit using the single fluorescence spectrum so that each of the fluorescent materials is displayed separately.

Multi-wavelength endoscopic system and image processing method using same

Disclosed are a nanoparticle sensor for measuring protease activity, for protease imaging, and a method for preparing the same. More specifically, the present invention relates to a nanoparticle sensor for measuring protease activity in which a fluorophore- and a quencher-conjugated peptide substrate is conjugated to a biocompatible polymer nanoparticle. The peptide substrate is specifically lysed by a protease. The sensor according to the present invention is capable of inhibiting emission of fluorescence with high extinctive activity of the quencher on a fluorescent material. But strong fluorescence is specifically emitted only if the peptide substrate is lysed by a specific protease. Therefore, the sensor is especially useful as a method for screening a novel drug such as a protease overexpression inhibitor, and early diagnosis of incurable diseases and various diseases such as autoimmune diseases including cancer, osteoarthritis, rheumatoid arthritis and dementia.

Nanoparticle sensor for measuring protease activity and method for manufacturing the same

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Seoul, South Korea

Seung-Jae Myung