Dong-a St Co., Ltd.

Samchully Pharm. Co.,ltd.

Seung-Bum Ha

Soon-Hoe Kim

Kyung-Il Kim

Yong-tae Kim

Weon-Bin Im

Sung-Hak Choi

Hyun-Jung Sung

Jung-Sang Park

Mi-Yeon Kim

Jae-Hoon Jeon

Soon-Jeong Kwon

Ji-Suk Yun

The present invention relates to a novel tricyclic benzoxaborole derivative, a preparation method thereof, and use of antibiotics pharmaceutical composition including the same as an active ingredient.

Tricyclic benzoxaborole compound, preparation method and use thereof

A method of preparing 2-deoxy-L-ribose represented by the following formula I is disclosed. The preparation method includes the steps of: treating L-arabinose with an alcohol solvent in the presence of an acid to prepare 1-alkoxy-L-arabinopyranose; allowing the prepared 1-alkoxy-L-arabinopyranose to react with acyl chloride so as to prepare 1-alkoxy-2,3,4-triacyl-L-arabinopyranose; brominating the alkoxy group of the prepared 1-alkoxy-2,3,4-triacyl-L-arabinopyranose to prepare a 1-bromo-2,3,4-triacyl compound; allowing the prepared compound to react with zinc in the presence of ethyl acetate and an organic base so as to prepare glycal; treating the glycal with an alcohol solvent in the presence of an acid to prepare 1-alkoxy-2-deoxy-3,4-diacyl-L-ribopyranose; treating the prepared 1-alkoxy-2-deoxy-3,4-diacyl-L-ribopyranose with a base to prepare 1-alkoxy-2-deoxy-L-ribopyranose; and hydrolyzing the prepared 1-alkoxy-2-deoxy-L-ribopyranose in the presence of an acid catalyst.

Preparation method of 2-deoxy-L-ribose

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Seoul, South Korea

Seung-Bum Ha