Vertex Pharmaceuticals, Inc.

Albert Einstein College of Medicine

Setu Roday

Michael Aaron Brodney

Dennis James Hurley

John Patrick Maxwell

Qing Tang

Kevin Michael Cottrell

Upul Keerthi Bandarage

Jinwang Xu

Simon Giroux

Adam R Looker

Michael John Boyd

Ales Medek

Yi Shi

Ronald Lee Grey, Jr

Stephen Andrew Thomson

Stefanie Roeper

Lev Tyler Dewey Fanning

Mac Arthur Johnson, Jr

Kevin Gagnon

Peter D Jones

Diane M Boucher

Philippe Marcel Nuhant

Brad D Maxwell

Rebecca Jane Swett

Timothy Lewis Tapley

Cavan McKeon Bligh

Sarathy Kesavan

Amy Beth Hall

Veronique Damagnez

Rupa Sawant

Sarah Carol Hood

Pedro Manuel Garcia Barrantes

Robert Francis Fimognari, Jr

Steven M Ronkin

Michael P Clark

Kathy Stavropoulos

Muna Shrestha

Kirk Overhoff

Mariam Zaky

Mei-Hsiu Lai

Marisa Sposato

Siying Liu

Gabrielle Simone Fleming

Robert Daniel Giacometti

Samantha Guido

Vern L Schramm

Michael Waldo

Mettachit Navamal

Mary Elizabeth Eccles

Joshua Kennedy Hussey

The disclosure provides compounds useful for treating alpha-1 antitrypsin deficiency (AATD), according to formula (I): tautomers thereof, pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable salts of the tautomers, deuterated derivatives of the compounds, deuterated derivatives of the tautomers, and deuterated derivatives of the salts, solid forms of those compounds and processes for making those compounds.

Modulators of alpha-1 antitrypsin

Novel compounds, compositions, and methods of using and preparing the same, which may be useful for treating alpha-1 antitrypsin deficiency (AATD).

This application provides fluorescent probes, substrates, kits and methods for detecting the presence or absence of an enzyme, such as ricin, that catalyzes the release of adenine from a GAGA RNA tetraloop.

Compounds and methods for detecting ricin and uses thereof

Growing community of inventors

Arlington, MA, United States of America

Setu Roday