Nisshin Flour Milling Co., Ltd.

Setsuko Mino

Haruhiko Kikuchi

Hiroaki Satoh

Koichiro Hagihara

Masashi Suzuki

Takeo Arai

Ruta Fukutomi

Toru Hayakawa

Masahiro Ueno

Yumiko Noguchi

Makoto Yanai

Kohei Inomata

Ryuta Fukutomi

Sugure Taniguchi

Haruko Eguchi

Nobuhiro Yahata

Kazuhiko Yamada

Toshio Suguro

Kiochiro Hagihara

An indazole compound having a piperazinyl moiety in the structure thereof, which is a 5-HT.sub.4 receptor agonist which is useful in the treatment of digestive tract disorders.

Indazole compound containing a monocyclic amine structure

Indazole derivatives having monocyclic amine

Diaminomethylidene derivatives

Pyrimidine derivatives

Compounds of formula (I) and pharmaceutically acceptable salts thereof are selective agonists for 5-HT.sub.4 receptors. ##STR1## wherein Ak is a C.sub.3 -C.sub.6 alkyl group, and R is a C.sub.2 -C.sub.6 alkyl group, a C.sub.3 -C.sub.6 alkenyl group, a C.sub.3 -C.sub.6 alkynyl group, a C.sub.3 -C.sub.7 cycloalkyl group or a C.sub.3 -C.sub.6 cycloalkylmethyl group.

5-HT.sub.4 receptor agonists

Diazabicyclo derivatives of formula (I) and pharmaceutically acceptable salts thereof: ##STR1## wherein R is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, alkoxyalkyl, oxoalkyl, alkoxycarbonylalkyl, alkoxycarbonyl, acyl, dialkylaminoalkyl, hydroxyalkyl, haloalkyl, cyanoalkyl, heterocycloalkyl, aryl, heteroarylalkyl or arylalkyl, the aryl group and the aryl moiety being optionally substituted by alkoxy, nitro, alkyl, amino or halo;

Diazabicyclo derivatives

Azabicyclo derivatives of formula (I) and pharmaceutically acceptable salts thereof: ##STR1## wherein A is a group of formula (a), (b) or (c): ##STR2## wherein R.sub.1 is hydrogen, C.sub.1 -C.sub.10 alkyl, aralkyl or di(C.sub.1 -C.sub.4) alkylamino(C.sub.1 -C.sub.6)alkyl;

Azabicyclo derivatives

Disclosed are compounds of formula (I) ##STR1## in which A is ##STR2## The compounds are selective antagonists of 5HT at 5-HT.sub.3 receptors and useful in the treatment of psychotic disorders, neurotic diseases, gastric stasis symptoms, gastrointestinal disorders, nausea and vomiting.

Piperidine derivatives

Azabicyclo derivatives and their use as antiemetics

Growing community of inventors

Ohimachi, Japan

Setsuko Mino