Panagene Inc.

Serka Kim

Jong Chan Lim

Hyunil Lee

Hee Kyung Park

Jung Hyun Min

Jae Jin Choi

Bong Ho Um

Hye Yeon Kim

Sung Jin Ha

Jin Won Yun

The present invention relates to a peptide nucleic acid (PNA) conjugated with multi-amine linkers, and a method to prepare the same and utilization thereof. More specifically, the method is characterized by conjugating monomers having multi-amine functionality sequentially at a PNA terminal, and effectively immobilizing the PNA conjugated with multi-amine linkers on a solid surface. A PNA array prepared using the PNA conjugated with multi-amine linkers exhibits improved sensitivity and specificity of signals for detecting target nucleic acids as compared to a PNA array using PNA probes having only one amine group. The PNA conjugated with multi-amine linkers can be utilized in nucleic acid detecting devices or kits for gene diagnosis such as PNA microarrays, PNA chips, PNA field-effect transistors and impedance detectors.

Peptide nucleic acids conjugated with multi-amine linkers and nucleic acid detecting device using the same

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Daejeon, South Korea

Serka Kim