Promega Corporation

Sergiy Levin

Thomas A Kirkland

Rachel Friedman Ohana

Keith V Wood

Harry Tetsuo Uyeda

Hui Wang

Poncho Meisenheimer

Wenhui Zhou

Joel R Walker

Carolyn Woodroofe Hitko

Ce Shi

Sergei Saveliev

Stephen J Dwight

Min Zhou

Robin Hurst

Ji Zhu

Zhiyang Zeng

Robert Kargbo

Valerie Ressler

Jun Zhang

Jean Osterman

Prabin Rai

The present invention provides haloalkane substrates, and linkers for connecting such substrates to functional elements (e.g., tags, labels, surfaces, etc.). Substrates and linkers described herein find use, for example, in labeling, detection, and immobilization of proteins, cells, and molecules. In particular, the linkers provided herein find use within substrates for dehalogenase variants that form covalent bonds with their haloalkane substrates.

Substrates for covalent tethering of proteins to functional groups or solid surfaces

Provided herein are surfactant compounds that can be used to aid in preparation of protein samples for analysis, for example by mass spectrometry.

Acid-labile surfactants

Provided herein are compositions and methods for photoaffinity labeling of molecular targets. In particular, probes that specifically interact with cellular targets based on their affinity and are then covalently linked to the cellular target via a photoreactive group (PRG) on the probe.

Photoaffinity probes

Provided herein are cell-permeable, cell-compatible, and chemoselectively-cleavable linkers for tethering (e.g., covalently) functional elements (e.g., a cellular interaction element and a capture element), and methods of use (e.g., intracellular capture and extracellular release of cellular targets) therewith.

Cell-permeable, cell-compatible, and cleavable linkers for covalent tethering of functional elements

Provided herein are palladium (Pd) catalysts with improved performance in biological environments. In particular, formulations, methods of preparations, and storage conditions are provided that provide improved performance of Pd catalysts under protein-rich conditions.

Palladium catalysts with improved performance in biological environments

Described herein are methods for the regioselective synthesis of substituted rhodamine dyes.

Methods for synthesizing rhodamine dyes

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San Luis Obispo, CA, United States of America

Sergiy Levin