Cranfield University

Sergiy Anatoliyovich Piletsky

Olena Volodimirivna Piletska

Anthony Peter Francis Turner

Uwe Schedler

Khalku Karim

Ian Alan Nicholls

Beining Chen

Alessandra Bossi

Ganna Valentinivna Elska

Richard Michael Day

Hakan Syen Andersson

Anthony P F Turner

Sreenath Subrahmanyam

David C Cullen

David Weston

A computer aided rational molecular design method that includes establishing a virtual library of functional monomers each having a portion that is capable of polymerizing and a functional group that is capable of interacting with a template molecule with the aid of a computer, designing a molecular model of a biological template molecule by a computer facilitated molecular mechanical method and screening said virtual library of functional monomers and selecting those monomers which have the highest binding score to the template molecule by their functional group.

Molecularly imprinted polymer

A template (a molecule preferably of molecular size &#x3e;500 Da, or a larger entity such as a cell, virus or tissue sample) is dissolved or suspended in a fluid. The fluid is frozen, and the template is removed (e.g. by dissolution or electrophoresis, or mechanically) to leave an 'imprinted' frozen fluid. This is capable of selectively adsorbing the template substance. It is usable as a separation medium, a recognition element in sensors and assays, and as a catalyst.

Selective binding materials

A polymer (e.g. a peptide) is produced by polymerizing monomers in the presence of a template, particularly a biologically active molecule or sample. The polymer is extracted and a soluble (preferably water-soluble) fraction is derived which specifically binds the template. Thus it can have complementary activity (e.g. biological). Applications include therapy, detection systems and separation systems.

Molecularly imprinted polymers produced by template polymerization

Reaction of a dialdehyde, particularly phthaldialdehyde (I), with R&mdash;Z where Z is a nucleophilic group (preferably SH) and R is polymerisable (e.g. allyl) gives a reactive thioacetal (V) which can react with an amine ligand L&mdash;NH to produce an isoindole (IV) which may be fluorescent. At some stage, generally before interaction with L&mdash;NH , the R groups are polymerised, possibly leading to self-assembly of the polymer on a metal or SH-bearing surface. Such a coated surface is useful as a transducer in assays or as a binding medium e.g. for chromatography.

Polymer for binding amine containing ligands and uses thereof

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Cranfield, United Kingdom

Sergiy Anatoliyovich Piletsky