Istituto Gentili S.p.a.

Abiogen Pharma S.p.a.

Boonville Limited

Sergio Rosini

Maurizio Mian

Silvia Trasciatti

Luciano Fontanelli

Giorgio Staibano

Giuseppe Guainai

Ruggero Aloisi

Dino Benetti

Disclosed are pharmaceutical compositions containing clodronic acid and hyaluronic acid or their salts as active constituents, mixed with suitable vehicles.

Pharmaceutical formulation for the treatment of osteoarthritis containing clodronic acid and hyaluronic acid

Catalytic monoclonal antibodies (abzymes) with selective protease activity in the pathologies characterized by the presence of plaques and fibrillar aggregates with protein component; methods for the preparation thereof and the use thereof as medicaments in the treatment of pathologies such as Alzheimer's disease, amyloidosis, atherosclerosis, prions diseases.

Catalytic monoclonal antibodies with protease activity for selective lysis of protein component of plaques aggregates pathological conditions

Mono- and disulfo-substituted anthraquinones and their use for the

Acylamino-alkyliden-hydroxy-bisphosphonic acids esters and salts

Anthraquinone compounds useful to treat osteoarticular conditions,

4,5-dihydroxy- and 4,5,8-trihydroxy-

Arylalkyl esters of

This invention relates to pharmaceutical compositions for the treatment of arthrosis by intraarticular administration of the compositions diluted in a suitable aqueous or lyophilized carrier, comprising an effective amount of diphosphonates and amino acids, specifically aminocarboxylic acids, added thereto as stabilizers. The invention also relates to a therapeutic method for the treatment of arthrosis by intraarticular administration of the compositions into the body of human beings and animals.

Pharmaceutical compositions based on diphosphonates for the treatment of

Biphosphonic acids of general formula I: ##STR1## in which R is a fluorine atom of a linear or branched alkyl radical containing between 1 and 5 carbon atoms, which may also be substituted by one or more amino groups of fluorine atoms or both amino groups and fluorine atoms, R' is hydroxy or fluorine, and their salts with an alkali metal, an organic base or a basic aminoacid, exhibit valuable properties in the treatment of urolithiasis or in the treatment as inhibitors of bone reabsorption. The compound 4-amino-1-hydroxybutan-1,1-biphosphonic acid is between 100 and 300 times more active than Cl.sub.2 MDP.

Pharmacologically active biphosphonates, process for the preparation

A pharmaceutical composition for the treatment of osteopathias is described which contains an effective amount of the active ingredient 6-amino-1-hydroxyhexane-1,1-diphosphonic acid or a pharmaceutically acceptable salt, ester, or a chelation complex with copper and inert carriers. The compositions are suitable for oral or systemic administration or topical application.

Pharmaceutical compositions for the treatment of osteopathias

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Pisa, Italy

Sergio Rosini