Unversität Zürich

Polyphor Ltd.

Polyphor Ag

Arpida Ag

Universitaet Zuerich

Sergio Lociuro

Daniel Obrecht

Frank Gombert

John Anthony Robinson

Barbara Romagnoli

Steven J Demarco

Jan Wim Vrijbloed

Kerstin Moehle

Reshmi Mukherjee

Jürg Zumbrunn

Christian Ludin

Heiko Henze

Kerstin Möhle

Laurent Schmitt

Ralf Loewe

Stephen Hawser

Juerg Zumbrunn

Jurg Zumbrunn

Reshimi Mukherjee

Steve J Demarco

Template-fixed &#x3b2;-hairpin peptidomimetics of the general formula (I) wherein Z is a template-fixed chain of 12, 14 or 18 &#x3b1;-amino acid residues which, depending on their positions in the chain (counted starting from the N-terminal amino acid), are Gly, NMeGly, Pro or Pip, or of certain types which, as the remaining symbols in the above formula, are defined in the description and the claims, and salts thereof, have CXCR4 antagonizing properties These &#x3b2;-hairpin peptidomimetics can be manufactured by a process which is based on a mixed solid- and solution phase synthetic strategy.

Template-fixed beta-hairpin peptidomimetics with CXCR4 antagonizing activity

Template-fixed &#x3b2;-hairpin peptidomimetics of the general formula (I) wherein Z is a template-fixed chain of 12, 14 or 18 &#x3b1;-amino acid residues which, depending on their positions in the chain (counted starting from the N-terminal amino acid), are Gly, NMeGly, Pro or Pip, or of certain types which, as the remaining symbols in the above formula, are defined in the description and the claims, and salts thereof, have CXCR4 antagonizing properties. These &#x3b2;-hairpin peptidomimetics can be manufactured by a process which is based on a mixed solid- and solution phase synthetic strategy.

Template-fixed &#x3b2;-hairpin peptidomimetics of the General Formula (I); wherein Zand Zare template-fixed chains of 4 and 6 or 5 and 7 &#x3b1;-amino acid residues and salts thereof. They have CXCR4-antagonizing properties and can be used as medicaments. These &#x3b2;-sheet peptidomimetics can be manufactured by a process which is based on a mixed solid- and solution phase synthetic strategy. 

Template-fixed peptidomimetics as medicaments against HIV and cancer

Template-fixed &#x3b2;-hairpin peptidomimetics of the general formula (I) wherein Z is a template-fixed chain of 12, 14 or 18 &#x3b1;-amino acid residues which, depending on their positions in the chain (counted starting from the N-terminal amino acid), are Gly, NMeGly, Pro or Pip, or of certain types which, as the remaining symbols in the above formula, are defined in the description and the claims, and salts thereof, have CXCR4 antagonizing properties. These &#x3b2;-hairpin peptidomimetics can be manufactured by a process which is based on a mixed solid&#x2014;and solution phase synthetic strategy.

Template-fixed &#x3b4;-hairpin peptidomimetics with CXCR4 antagonizing activity

The invention relates to novel specifically trifluoromethyl and halogen substituted 1,3-diphenyl ureas and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects like the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as anti-infectives.

Diphenyl urea derivatives

Growing community of inventors

Reinach, Switzerland

Sergio Lociuro