Produits Chimiques Auxiliaires Et De Synthese

Produits Chimiques Auxiliaries Et De Synthese

Sergio Kreimerman

Jean-Marie Schneider

Jonathan Madec

Gerard Guillamot

Gérard Guillamot

The present patent application relates to a process for preparing cinacalcet or a pharmaceutically acceptable salt thereof, which comprises reacting 3-trifluoromethylbenzaldehyde having the following formula (II) with the phosphorus-comprising derivative having the following formula (III) in which Rand R, which may be identical or different, are each a (C-C)alkyl group. The present invention also relates to the phosphorus-comprising derivative having the formula (III), to the use thereof and to the process for preparing same. The present invention also relates to the phosphate salt of cinacalcet and to uses thereof.

Process for preparing cinacalcet and pharmaceutically acceptable salts thereof

The present patent application relates to a process for preparing, cinacalcet or a pharmaceutically acceptable salt thereof, which comprises reacting 3-trifluoromethylbenzaldehyde having the following formula (II) with the phosphorus-comprising derivative having the following formula (III) in which Rand R, which may be identical or different, are each a (C-C)alkyl group. The present invention also relates to the phosphorus-comprising derivative having the formula (III), to the use thereof and to the process for preparing same. The present invention also relates to the phosphate salt of cinacalcet and to uses thereof.

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Houdan, France

Sergio Kreimerman