Lawrence Livermore National Security, LLC

Merck Sharp + Dohme Corp.

Sergio E Wong

Felice C Lightstone

John M Finn

Junhu Zhang

Xiaoming Li

Zhiyong Chen

Leslie William Tari

Thanh To Lam

Michael Trzoss

Suk Joong Lee

Daniel Bensen

Toan B Nguyen

Michael E Jung

Douglas W Phillipson

Min Teng

Joe H Satcher, Jr

Roger D Aines

Matthew A Coleman

Allen Borchardt

Dan McFarland Park

Brent W Segelke

Howard Harris

Yongqin Jiao

Patrik D'haeseleer

Paul Aristoff

Mimi-Cho Yung

Kenneth W Overton

Sarah Elyse Baker

Carlos A Valdez

John F Finn

Joshuah K Stolaroff

Edmond Y Lau

Voon Ong

Allen John Borchardt

This disclosure provides microbes engineered to detect virulent and spore states of pathogens and release an appropriate therapeutic response accordingly and compositions and methods of use of the same.

Dynamically-adaptive live therapeutic agents and methods of use thereof

Disclosed herein are compounds having the structure of Formula I and pharmaceutically suitable salts, esters, and prodrugs thereof that are useful as antibacterially effective tricyclic gyrase inhibitors. In addition, species of tricyclic gyrase inhibitors compounds are also disclosed herein. Related pharmaceutical compositions, uses and methods of making the compounds are also contemplated.

Tricyclic Gyrase inhibitors

Disclosed herein are compounds having the structure of Formula I and pharmaceutically suitable salts, esters, and prodrugs thereof that are useful as antibacterially effective tricyclic gyrase inhibitors. Related pharmaceutical compositions, uses and methods of making the compounds are also contemplated.

Tricyclic gyrase inhibitors

The creation of a catalyst that can be used for a wide variety of applications including the steps of developing preliminary information regarding the catalyst, using the preliminary information to produce a template of the catalyst, and using the template of the catalyst to produce the catalyst.

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A system is provided that substantially increases the efficiency of COcapture and removal by positioning a catalyst within an optimal distance from the air-liquid interface. The catalyst is positioned within the layer determined to be the highest concentration of carbon dioxide. A hydrophobic tether is attached to the catalyst and the hydrophobic tether modulates the position of the catalyst within the liquid layer containing the highest concentration of carbon dioxide.

Tethered catalysts for the hydration of carbon dioxide

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Tracy, CA, United States of America

Sergio E Wong