Fin-ceramica Faenza S.p.a.

Fidia Advanced Biopolymers S.r.l.

Anika Therapeutics S.r.l.

Lipobank S.r.l.

Sergio Di Fede

Daniele Pressato

Lanfranco Callegaro

Anna Tampieri

Maurilio Marcacci

Elena Landi

Claudio De Luca

Roberta Martinetti

Laura Dolcini

Carlo Ventura

The present invention relates to a multilayer structure () including a first upper layer () consisting of an organic matrix including collagen and at least a lower layer () consisting of a composite matrix including hydroxylapatite and collagen. Furthermore, the present invention relates to a cartilaginous substitute including said multilayer structure () as well as an osteochondral substitute including said multilayer structure (). Finally, the present invention relates to the use of said multilayer structure () for the preparation of said cartilaginous substitute and said osteochondral substitute for the treatment of cartilaginous defects and osteochondral defects or for the neo-formation of a cartilaginous tissue and/or a subchondral bone tissue.

Cartilaginous and osteochondral substitute comprising multilayer structure and use thereof

The object of the present invention is a process for obtaining a bone substitute of given chemical and physical characteristics and entirely similar to those of the mineral portion of natural bone tissue. The process substitutes Ca ions with Mg ions in a porous matrix; the process comprises a phase of contacting the matrix with a saline aqueous solution containing an effective quantity of Mg ions at a pressure greater than or equal to 1 bar.

Process for the preparation of a biomimetic bone substitute and its uses

The invention relates to use of a biological material containing cells supported on three-dimensional scaffolds containing at least one hyaluronic acid derivative for the preparation of grafts suitable for application by arthroscopy, and a kit of surgical instruments for implanting said biological material by arthroscopy.

Use of a biological material containing three-dimensional scaffolds of hyaluronic acid derivatives for the preparation of implants in arthroscopy and kit for instruments for implanting said biological material by arthroscopy

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Bologna, Italy

Sergio Di Fede