Cephalon, Inc.

Sigma-tau Industrie Farmaceutiche Riunite S.p.a.

Millennium Pharmaceuticals Limited

Cell Therapeutics, Inc.

Sergio De Munari

Ernesto Menta

Alberto Bernareggi

Sankar Chatterjee

Mohamed A Iqbal

Ambrogio Oliva

Raffaella Bernardini

Germano D'Arasmo

Paolo G Cassara

Edmondo Ferretti

Patricia A Messina McLaughlin

Piero Melloni

Marco Santagostino

Marco Frigerio

Patrizia Ferrari

Mauro Gobbini

Marco Torri

Elena Folpini

Simona Sputore

Giorgio Fedrizzi

Mario Grugni

Gianluca Pardi

Paolo Pavesi

Giulio Mariotti

Gabriella Pezzoni

Paolo Nicoli

Fulvio Serra

Germano D'arasmo

Patricia A Messina Mclaughlin

The present invention provides boronic acid compounds, boronic esters, and compositions thereof that can modulate apoptosis such as by inhibition of proteasome activity. The compounds and compositions can be used in methods of inducing apoptosis and treating diseases such as cancer and other disorders associated directly of indirectly with proteasome activity.

Proteasome inhibitors and methods of using the same

A compound of general formula (I): in which: R is selected from the group consisting of (C-C)alkyl, (C-C)alkenyl, aryl, (C-C)aralkyl; n and m are each independently an integer of two to eight; p is one or two; A is selected from the group consisting of &#x2014;B&#x2014;, &#x2014;B&#x2014;(CH)&#x2014;B&#x2014;, &#x2014;B&#x2014;(CH)&#x2014;B&#x2014;(CH)&#x2014;B&#x2014;, wherein r and z are an integer from 2 to 8, B is a &#x2014;NR&#x2014; or &#x2014;N(R)1/pQgroup, in which R1 is selected from hydrogen, (C-C)alkyl, (C-C)acyl, tert-butoxycarbonyl, and Ris selected from hydrogen and (C-C)alkyl; Qis an anion selected from chloride, bromide, iodide, nitrate, sulphate, hydrogen sulphate, perchlorate, RCOOwherein Rhas the same meanings as R, independently from one another and R&#x2014;O&#x2014;SOwherein Ris (C-C)alkyl with the proviso that, when Qis selected from chloride, bromide, iodide, nitrate, sulphate, hydrogen sulphate, perchlorate, R is not (C-C)alkyl. 

Bis-platinum complexes with antitumor activity

New seco-D steroid derivatives, processes for their preparation and pharmaceutical compositions are provided, which are active on the cardiovascular system. The seco-D steroid derivatives have the following general formula (I): ##STR1##

Seco-d steroids active on the cardiovascular system, processes for their

6-hydroxy and 6-oxo-androstane derivatives of formula (I), active on the cardiovascular system. ##STR1## wherein: the symbol A represents CH--OR, C.dbd.N--OR, CH--CH.dbd.N--OR and C.dbd.CH--N--OR; and R.sup.1, R.sup.2 and R.sup.3 are as defined herein.

6-Hydroxy and 6-oxo-androstane derivatives active on the cardiovascular

Growing community of inventors

Milan, Italy

Sergio De Munari