Gendiag.exe, S.l.

Progenika Biopharma S.a.

Genincode Plc

Sergio Castillo Fernandez

Roberto Elosua Llanos

Eduardo Salas Perez-Rasilla

Jaume Marrugat De La Iglesia

Joan Salgado Gómez

Joan Salgado Gomez

Antonio Martinez Martinez

Miroslava Ogorelkova

Eduardo Salas

José Manuel Soria

Joan Vila

Diego Tejedor Hernandez

Miguel Mallen Perez

Eduardo Salas Pérez-Rasilla

José Maria Ordovás Munoz

Jose Maria Ordovás Munoz

Pedro Mata Lopez

Rodrigo Alberto Alonso Karlezi

Pilar Mozas Alonso

Gilberto Reyes Leal

Miguel Pocovi Mieras

Jose Maria Ordovas Munoz

José María Ordovás Muñoz

The invention relates to a method for the reclassification of a subject to a more appropriate risk assessment to that obtained using the algorithms for such risk estimation such us but not limited to Framingham, Regicor, Score, Procamor Qrisk based on the presence of different polymorphisms. The invention also relates to a method for determining the risk of suffering a cardiovascular disease by combining the absence or presence of one or more polymorphic markers in a sample from the subject with conventional risk factors for CVD as well as computer-implemented means for carrying out said method.

Cardiovascular disease

The invention relates to a method for a more appropriate thromboembolic event risk assessment based on the presence of different genetic variant. The invention also relates to a method for determining the risk of suffering a thromboembolism disease by combining the absence or presence of one or more polymorphic markers in a sample from the subject with conventional risk factors for thromboembolism as well as computer-implemented means for carrying out said method.

Thromboembolic disease markers

The invention relates to a method for determining the risk of suffering a cardiovascular disease based on the presence of different polymorphisms as well as to kits for practicing the above method. The invention also relates to a method for determining the risk of suffering a cardiovascular disease by combining the absence or presence of one or more polymorphic markers in a sample from the subject with conventional risk factors for CVD as well as computer-implemented means for carrying out said method.

Method for detecting polymorphisms

The invention relates to extracorporeal methods of analyzing the presence or absence of mutations which cause familial hypercholesterolemia. The inventive methods describe the way in which said mutations can be detected using a DNA sample from an individual and comprising the following: chain reaction of the polymerase with primers which are complementary to the low-density lipoprotein receptor gene; analysis of the amplified product by sequencing; restriction analysis; single strand conformation polymorphism techniques; heteroduplex analysis and analysis of a device on top of a biochip glass support on which oligonucleotide probes are disposed, which can be used to detect the aforementioned mutations in the DNA.

Method and device for the detection of mutations in isolated gene sequences of the low-density lipoprotein receptor (LDL-r) which is associated with familial hypercholesterolemia

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Barcelona, Spain

Sergio Castillo Fernandez