Nogra Pharma Limited

Giuliani S.p.a.

Giuliani International Limited

Giuliana S.p.a.

Sergio Baroni

Salvatore Bellinvia

Francesca Viti

Giammaria Giuliani

Anna Benedusi

Giancarlo Naccari

Barbara Marzani

Ralf Paus

Antonio Mascolo

Jeremy Cheret

Elena Pini

Giovanni Monteleone

Giovanni Pantini

Marco Gobbetti

Raffaella Di Cagno

Hanns Hatt

Benedetto Grimaldi

Daniela Pinto

Antonio Limitone

Carlo Giuseppe Rizzello

Raffaella Gandolfi

Yuval Ramot

Astrid Becker

Nathan Hawkshaw

Mauro Picardo

Jérémy Cheret

Pierre Desreumaux

The present disclosure is directed in part to methods of treating fibrosis, e.g., hepatic fibrosis and/or intestinal fibrosis, comprising administering to a patient in need thereof an effective amount of a disclosed compound.

Methods of treating fibrosis

The present invention relates to the use of iminooxothiazolidine derivatives for preventing or treating hair growth disorders. The iminooxothiazolidine derivatives may be formulated as compositions suitable for either the systemic administration or the local application to the scalp.

Composition for prevention and treatment of hair growth disorders

The present invention concerns the use of selected compounds in a cosmetic skincare treatment or in the treatment of certain skin, scalp or mucosal diseases. The invention also provides a composition for topical use incorporating a pharmaceutically or cosmetically effective amount of a compound for preventing or treating skin or mucosal diseases having an inflammatory component or for reducing the redness or irritation of skin or mucosae.

Compounds for preventing and treating skin or mucosal affections having an inflammatory component

The invention relates to a synergistic composition comprising a dry extract of plant of genusand a compound promoting autophagy selected from biotin and R-N1-spermidine or a salt thereof, wherein R is hydrogen or methyl and mixtures thereof. The synergistic compositions according to the invention may be in the form of a topical formulation or oral formulation and is useful as a promoter of autophagy especially in cells of human scalp hair follicles and in promoting hair growth and/or in the treatment of hair thinning or hair loss.

Synergistic composition as a promoter of autophagy

Disclosed herein are methods for treating hair related disorders, including compounds that may be specific or modulate PPAR receptors.

Methods of treating hair related conditions

The invention concerns the use of compounds of general formula (I): (I) wherein: Rand Rform together a double bond, or Rand Rform together a cyclopropyl group; R, Rare the same or different and independently chosen from hydrogen, methyl, or Rand Rform together a double bond; R, R6 are the same or different and independently chosen from hydrogen, methyl; or Rand Rform together a double bond, or Rand Rform together a cyclopropyl group; R=methyl, or ethyl; R=hydrogen, or methyl, for promoting hair growth and/or inhibiting or delaying hair loss in the human scalp, and cosmetic and pharmaceutical compositions suitable for such use.

Compounds for promoting hair growth and/or inhibiting or delaying hair loss in humans, and compositions for such uses

The invention relates to compounds having general formula (I): where R&#x2550;H, CH&#x2014;OH, CH&#x2014;O&#x2014;CO&#x2014;CH, CH&#x2014;O&#x2014;CO-Ph (Ph=phenyl) R'&#x2550;H, CH&#x2014;O&#x2014;CO&#x2014;CH, CH&#x2014;O&#x2014;CO-Ph (Ph=phenyl) Ar=phenyl, 3-methoxy-4-hydroxy phenyl, 2-furyl. These are compounds having antioxidant activity against free radicals together with anti-inflammatory activity, the compounds being useful as active ingredients for the preparation of pharmaceutical dermatological or cosmetic compositions for skin care. 

Compounds having antioxidant activity against free radicals and anti-inflammatory activity, and corresponding pharmaceutical or cosmetic compositions for skin care

The present invention provides pharmaceutical formulations for oral administration of antisense oligonucleotides, such as antisense oligonucleotides against SMAD7. The pharmaceutical formulations can be used to treat Crohn's disease, ulcerative colitis and chronic inflammatory bowel disease.

Antisense compositions and methods of making and using same

Disclosed herein are compounds that may be specific to PPAR and/or EGF receptors, and methods of making and using same.

Alkylamido compounds and uses thereof

The present invention relates to compounds comprising the general formula (I), in which Rand R, which may be identical or different, are selected from the group comprising &#x2014;H or a linear or branched alkyl group having from 1 to 6 carbon atoms or together form an aromatic or aliphatic ring with 5 or 6 atoms; Y and Z, which may be identical or different, are selected from the group comprising &#x2014;H, &#x2014;OH, &#x2014;COOH, &#x2014;OR, &#x2014;CH(OR)COOH, in which Ris selected from H, phenyl, benzyl, &#x2014;CFor &#x2014;CFCF, vinyl, allyl and a linear or branched alkyl group having from 1 to 6 carbon atoms.

Compounds and their salts specific to the PPAR receptors and the EGF receptors and their use in the medical field

The invention relates to the 4-((2E,4E,6E)-octa-2,6,4-trienamid)butanoic acid; its use in the therapeutic and cosmetic field for topical application to the skin to achieve a combined antioxidant activity against ROS together with an anti-inflammatory effect and an effect of promoting the production of hyaluronic acid, so as to oppose at the same time the oxidizing action of free radicals and inflammatory effects, in order to preserve the physiological conditions of human epidermis and skin homeostasis and prevent skin aging (anti-aging); the compositions for therapeutic and cosmetic use which comprise 4-((2E,4E,6E)-octa-2,6,4-trienamid)butanoic acid as active ingredient, formulated with excipients for topical use suitable for local administration on the skin.

Growing community of inventors

Villa D'adda, Italy

Sergio Baroni