Other

Alla Chem, LLC

Ivashchenko, Andrey Alexandrovich

Sergey Yevgenievich Tkachenko

Nikolay Filippovich Savchuk

Ilya Okun

Andrey Alexandrovich Ivashchenko

Alexander Khvat

Alexandre Vasilievich Ivachtchenko

Oleg Dmitrievich Mitkin

Yan Lavrovsky

Jean-Michel Andre Vernier

William Charles Ripka

David J Matthews

Vadim Bichko

Alexander Vasilievich Ivashchenko

Volodymyr Mikhailovich Kysil

Patrick O'Connor

John May

Evgueni Borisovich Frolov

Dmitri Vladimirovich Kravchenko

Borys Rogovoy

Sergey Malyarchuk

Alexandr Sergeevich Kyselvev

Alexander Vasilievich Ivachtchenko

Ilya Matusovich Okun

The invention relates to pharmacology and medicine, more particularly to novel pharmaceutical compositions and pharmaceutical kits for treating bacterial infections, and to novel method for treating diseases caused by bacterial infections including tuberculosis. The pharmaceutical composition is disclosed comprising Rifamycin and interferon inducer in pharmacologically effective doses, and also pharmaceutical kit for treating diseases caused by bacterial and healthcare acquired infections, comprising pharmacologically effective doses of Rifamycin in the form of a tablet, a capsule or an injection, interferon inducer in the form of a tablet, a capsule or an injection, and instruction for administration of the components of this pharmaceutical kit.

Pharmaceutical composition and kit for treating bacterial infections

The invention relates to antagonists of serotonin 5-HTreceptors simultaneously regulating homeostasis of Caions in cells, representing substituted 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indoles of the general formula 1, pharmaceutically acceptable salts and/or hydrate thereof. In the general formula 1: Rrepresents amino group substituent selected from optionally substituted C-Calkyl; Ris one or more substituents selected from hydrogen, halogen, C-Calkyl, CF, OCF; Ar is phenyl optionally substituted with halogen, C-Calkyl, C-Calkoxy, substituted amino group, or CF; or optionally substituted aromatic 6-membered heterocycle comprising 1-2 nitrogen atoms in the cycle; W represents ethylene group &#x2014;CH&#x2014;CH&#x2014;, ethenyl group &#x2014;CH&#x2550;CH&#x2014;, or ethynyl group &#x2014;C&#x2261;C&#x2014;. The invention also relates to the novel compounds selected from the compounds of the general formula 1, methods for their preparation, pharmaceutical compositions and methods of their use.

Substituted 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indoles, methods for the production and use thereof

Described herein are compounds, pharmaceutical compositions and methods for the inhibition of Hedgehog signaling. Said compounds, pharmaceutical compositions and methods have utility in the treatment of human and veterinary diseases and disorders.

Antagonist of smoothened

The invention relates to novel heterocyclic compounds and to the use thereof, to pharmaceutical compositions containing said chemical compounds as an active ingredient and to the use thereof for producing medicinal preparations for the human being and warm-blood animals for treating diseases caused by the aberrant activity of an Hedgehog (Hh)-signal system, in particular oncological diseases. The invention also relates to the use of the above-mentioned compounds in the form of 'molecular pharmacological tools' for examining (in vitro and in vivo) the biochemical features of the Hh-signal system, in particular, the interaction of Hh protein and transmembrane proteins, namely, suppressor Patched (Ptc) and protooncogenic proteins. The eight groups of the claimed compounds comprise the derivatives of 2,6-dihydro-7H-pyrazolo[3,4-d]pyridazine-7-one and 1,4-dihydropyrazolo[3,4-b][1,4]thiazine-5-one; N-acidylated 4-imidazo[1,2-a]pyrimidine-2-il-anilines; ([4H-thino[3,2-b]pyrrol-5-il) carbonyl]piperidine-4-carbonic acid amides; 2-(4carbomoilpyperidine-1-il)-isonicotinic acid amides; N-sylphonyl-1,2,3,4-tetrahydroquinoline-6-carbonic acid amides; and pyridine 2-amino-4,5,6,7-tetrahydrothieno[2,3-c]N-acidylated 3-azole derivatives.

Heterocyclic inhibitors of an Hh-signal cascade, medicinal compositions based thereon and methods for treating diseases caused by the aberrant activity of an Hh-signal system

The invention relates to novel substituted indoles, to the use thereof in the form of pharmacological composition substances and to use of said composition for producing medicinal preparations used for preventing and treating viral diseases, in particular caused by viruses of infectious hepatitis (HCV, HBV), human immune deficiency (HIV), atypical pneumonia (SARS) and bird flu. The invention proposes novel substituted indoles of general formula (1) or the racemates or the optical isomers or the pharmaceutically acceptable salts and/or hydrates thereof, wherein R, Rand Rindependently of each other are an aminogroup substituent selected for hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted aryl or optionally substituted heterocyclyl, or Rand Rtogether with a nitrogen atom, with which they are bound, form through Rand Roptionally substituted azaheterocyclyl or guanidyl; Ris analkyl substituent selected from hydrogen, an optionally substituted mercaptogroup, optionally substituted aminogroup and optionally substituted hydroxyl; Ris lower alkyl, Ris an hydrogen atom or Rtogether with an oxygen atom with which it is linked or Rtogether with a nitrogen atom with which it is linked close, via Rand Ran oxazine cycle; Ris a cyclic system substituent selected for hydrogen, a halogen atom, cyanogroup, optionally substituted aryl or substituted heterocyclyl. 

Substituted indoles and a method for the production and use thereof

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San Diego, CA, United States of America

Sergey Yevgenievich Tkachenko