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Sergey V Kulikov

Andrey S Simbirtsev

Alexander A Kolobov

Alexander U Kotov

Oleg A Kaurov

Natalia V Pigareva

Natalia M Kalinina

Sergey A Ketlinsky

Vladimir M Shpen

Alexey N Prusakov

The new class of synthetic immunomodulatory molecules having a .gamma.-L-glutamyl- moiety at the amino terminus are provided as illustrated by Formula 1. ##STR1## In Formula 1, the Greek symbols designate the noted carbon atoms, R is hydrogen, acyl or alkyl, and X is an aromatic or heterocyclic amino acid or its derivative. Included as members of the new class (in addition to Bestim, .gamma.-L-glutamyl-L-tryptophan) are those compounds where R=hydrogen and X=L-tryptophan, such as .gamma.-L-glutamyl-N.sub.in -formyl-L-tryptophan, N-methyl-.gamma.-L-glutamyl-L-tryptophan, N-acetyl-.gamma.-L-glutamyl-L-tryptophan, and .gamma.-L-glutamyl-.beta.-thienyl-D-alanylamide. A preferred embodiment, termed 'BESTIM,' has the chemical structure of .gamma.-L-glutamyl-L-tryptophan.

.gamma.-L-glutamyl containing immunomodulator compounds and methods

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St.-Petersburg, Russia

Sergey V Kulikov