Applied Biosystems, LLC

Sergey V Ermakov

Mark F Oldham

Charles Stuart Vann

Joy Roy

Dennis Lehto

Ian A Harding

Yuh-Min Chiang

Nigel P Beard

Umberto Ulmanella

David M Liu

Alexander A Dromaretsky

Joon Mo Yang

John R Van Camp

Maryam Shariati

Min Yue

Systems and methods for multiple analyte detection include a system for distribution of a biological sample that includes a substrate, wherein the substrate includes a plurality of sample chambers, a sample introduction channel for each sample chamber, and a venting channel for each sample chamber. The system may further include a preloaded reagent contained in each sample chamber and configured for nucleic acid analysis of a biological sample that enters the substrate and a sealing instrument configured to be placed in contact with the substrate to seal each sample chamber so as to substantially prevent sample contained in each sample chamber from flowing out of each sample chamber. The substrate can be constructed of detection-compatible and assay-compatible materials.

Systems and methods for multiple analyte detection

The present teachings provide a fluid processing device adapted to produce different oligomers in a plurality of respective reaction sites. The fluid processing device can comprise a first manifold for delivering reactants to the plurality of reaction sites, and a second manifold for removing waste from, and optionally delivering wash fluid to, the plurality of reaction sites. Surface tension control valves can be disposed in fluid communication with the first manifold and can selectively allow reactants and/or fluids into the reaction sites. A method of making oligonucleotides is also provided.

Fluid processing device for oligonucleotide synthesis and analysis

The present teachings relate to surface tension controlled valves used for handling biological fluids. The valves controlled by optically actuating an electro-wetting circuit.

Surface tension controlled valves

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Castro Valley, CA, United States of America

Sergey V Ermakov