Integrated Biotherapeutics, Inc.

Sergey Shulenin

Mohammad Javad Aman

Rajan Prasad Adhikari

Hatice Karauzum

Frederick Wayne Holtsberg

Kelly Lyn Warfield

Tam Nguyen

Sathya Venkataramani

Jawad Sarwar

Tam Luong Nguyen

The present disclosure provides immunogenic compositions useful in prevention and treatment ofinfection. In particular, the disclosure provides delta toxin and phenol-soluble modulin peptides as well as mutants, fragments, variants or derivatives thereof. The disclosure further provides multivalent oligopeptides, fusion proteins comprising two or more staphylococcal proteins, e.g., DT, PSM, alpha hemolysin, leukocidin, superantigen, or any fragments, variants, derivatives, or mutants thereof fused together as a single polypeptide in any order.

Toxoid peptides derived from phenol soluble modulin, delta toxin, superantigens, and fusions thereof

The present disclosure provides immunogenic compositions useful in prevention and treatment ofinfection. In particular, the disclosure provides methods of inducing an immune response against a panton-valentine leukocidin (PVL)-expressing, methods of preventing or treatinginfections, and composition for preventing or treatinginfections.

Immunogenic composition comprising Panton-Valentine Leukocidin (PVL) derived polypeptides

Growing community of inventors

Point of Rocks, MD, United States of America

Sergey Shulenin