Medivation Technologies, Inc.

Caritas St. Elizabeth's Medical Center of Boston, Inc.

D2e, LLC

Sergey O Bachurin

Nadezhda Sergeevna Beznosko, Legal Representative

Bogdan K Beznosko

Sarvajit Chakravarty

Sundeep Dugar

Rajendra Parasmal Jain

David T Hung

Andrew Asher Protter

Gregory F Oxenkrug

Nikolai Serafimovich Zefirov

Vladimir V Grigoriev

Elena F Shevtsova

Alexey Aksinenko

Sergey Sablin

Anatoly K Ustinov

Julia Beznosko, Legal Representative

Vladimir Sokolov

This disclosure relates to new tetracyclic compounds that may be used to modulate a histamine receptor in an individual. The compounds in one embodiment are tetracyclic [4,3-b]indoles. Pharmaceutical compositions comprising the compounds are also provided, as are methods of using the compounds in a variety of therapeutic applications, including the treatment of a cognitive disorder, psychotic disorder, neurotransmitter-mediated disorder and/or a neuronal disorder.

Tetracyclic compounds

Some exemplary embodiments comprise fluoro-containing derivatives of pyrido[4,3-b]indoles (and exemplary methods of making the same) that may be administered to a mammal (including a human) in an effective amount for potential use in the treatment or prophylaxis of neurological disorders including AD, mild cognitive impairment, senile and vascular dementia, HD, ALS, Parkinson's disease, AIDS-related dementia, ischaemic cerebral pathologies, neuropathic pain, ADHD (attention deficit disorder/hyperactivity syndrome), eating disorders such as anorexia and bulimia, panic attacks, withdrawal from drug abuse such as cocaine, ethanol, nicotine and benzodiazepines, schizophrenia (in particular the cognitive deficit of schizophrenia), stroke and also disorders associated with spinal trauma and/or head injury. These derivatives may also be useful for the treatment of borderline personality disorder, obesity, and for use as geroprotectors. The compounds may also be used as 'pharmacological tools' for an investigation of the mechanism of protection against neurodegeneration disorders in vivo or in vitro.

Fluoro-containing derivatives of hydrogenated pyrido[4,3-b]indoles with neuroprotective and cognition enhancing properties, process for preparing, and use

Compositions comprising 5-methoxy-carbonylamino-N-acetyltryptamine compounds and derivatives thereof for the treatment of depression are disclosed.

5-methoxy-carbonylamino-N-acetyltryptamine compounds and derivates thereof

Growing community of inventors

Chernogolovka, Russia

Sergey O Bachurin