Pfizer Corporation

Pharmacia & Upjohn Company

Sergey Gregory Wolfson

Walter Morozowich

Malcolm Wilson Moon

Patrick J Lennon

Michael John Hawley

Mark Peter Warchol

Dominique Bonafoux

Sue K Cammarata

Craig D Wegner

Mark Kontny

Ivan Richards

Karen Patrice Kolbasa

Eric Jon Jacobsen

Michele A Promo

Horng-Chih Huang

Susan J Hartmann

Brad A Acker

Jin Xie

Brad Alan Acker

Michele Ann Promo

Described herein are pyrrolo[2,3-d]pyrimidine compounds, their use as Janus Kinase (JAK) inhibitors, pharmaceutical compositions containing these compounds, and methods for their preparation. 

Pyrrolo[2,3-D]pyrimidine compounds

The compound 2-[(1R)-3-(diisopropylamino)-1-phenylpropyl]-4-(trifluoromethyl) phenol may be used to prepare the compound (3R)-3-[2-hydroxy-5-(trifluoromethyl)phenyl]-N,N-diisopropyl-N-methyl-3-phenylpropan-1-aminium bromide by reaction with methyl bromide.

Phenol derivative

Novel quaternary ammonium compounds of the formulaand any stereoisomers thereof, wherein R, Rand Rindependently represent C-Calkyl, optionally substituted with phenyl or hydroxyl, or both, and wherein any two of R, Rand Rmay form a ring together with the quaternary ammonium nitrogen; Rrepresents &#x2014;H, &#x2014;CH, or &#x2014;CO&#x2014;R, wherein Rrepresents &#x2014;(C-Calkyl), &#x2014;(C-Calkoxy), or &#x2014;NRR, wherein Rand Rindependently represent &#x2014;H or &#x2014;(C-Calkyl); R, Rand Rindependently represent &#x2014;H, &#x2014;OCH, &#x2014;OH, &#x2014;CONH, &#x2014;SONH, &#x2014;F, &#x2014;Cl, &#x2014;Br, &#x2014;I, &#x2014;CF, or &#x2014;(C-Calkyl), optionally substituted with one or two &#x2014;OH, &#x2014;(C-Calkoxy), &#x2014;COOH, or &#x2014;CO&#x2014;O&#x2014;(C-Calkyl); and Xrepresents an anion of a pharmaceutically acceptable acid, the compounds for use as medicaments, use of the compounds for the manufacture of specific medicaments, and pharmaceutical compositions comprising the compounds. The present invention also concerns a method of treatment involving administration of the compounds.

Quaternary ammonium compounds

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Chesterfield, MO, United States of America

Sergey Gregory Wolfson