National Institutes of Health, a Component of the US Dept. of Health & Human Services

Other

University of Illinois

Vanderbilt University

Sergey G Tarasov

Nadya Tarasova

Christopher J Michejda

Vadim Gaponenko

Michael C Dean

Alan O Perantoni

Olga Timofeeva

Alla Ivanova

Joseph Kates

A peptide or peptidomimetic comprising the amino acid sequence of the second helix of a STAT protein, or a variant of such sequence, wherein the peptide or peptidomimetic comprises about 40 or fewer amino acids and binds to a STAT protein, as well as a method of inhibiting a STAT protein in a cell, a method of treating or preventing a disease associated with STAT overexpression in a host, and related compounds, compositions, and methods.

Peptide-based stat inhibitor

The invention provides a peptide or peptidomimetic that is derived from or based upon the amino acid sequence of the C-terminal &#x3b1;-helix or hypervariable region (HVR) or a Ras protein, a nucleic acid encoding the peptide or peptidomimetic, and methods employing the same.

Lipopeptide inhibitors of RAS oncoproteins

The invention provides a method of handling a hydrophobic agent, which method comprises (a) combining in an aqueous solution (i) a hydrophobic agent and (ii) an isolated peptide that is a structural analog of a transmembrane domain of an integral membrane protein, wherein one terminus of the peptide has one or more negatively charged residues, and (b) allowing the peptide to self-assemble into nanoparticles, wherein the nanoparticles comprise the hydrophobic agent.

Self-assembling nanoparticles composed of transmembrane peptides and their application for specific intra-tumor delivery of anti-cancer drugs

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Frederick, MD, United States of America

Sergey G Tarasov