Ausculsciences, Inc.

Other

Sergey A Telenkov

Simon Martin

Brady Nicholas Laska

Md Shahidul Islam

Daniel Labonté

Robert J Griffin

Jun Zhou

Jikang Zeng

Mark W Armstrong

David Gloag

Camilla Jastrzebski

Steven P Morton

Andreas Mandelis

Robin F Castelino

Bahman Lashkari

Anthony Dewar

At least one sound generator operatively coupleable to a corresponding at least one auscultatory sound-or-vibration sensor provides for generating a corresponding at least one sound signal that is applied to the corresponding at least one auscultatory sound-or-vibration sensor. For each sound generator and corresponding auscultatory sound-or-vibration sensor operatively coupled thereto, a communications interface provides for receiving a corresponding auscultatory sound signal from the corresponding auscultatory sound-or-vibration sensor, and at least one computer processor operatively coupled to the communications interface provides for either generating, or causing to be generated, an electronic audio signal that drives the sound generator, causing a corresponding at least one sound signal to be generated thereby, and at least one computer processor provides for analyzing the auscultatory sound signal from the corresponding auscultatory sound-or-vibration sensor responsive thereto for determining whether or not the corresponding at least one auscultatory sound-or-vibration sensor is functioning properly.

Coronary artery disease detection signal processing system and method

A metallic diaphragm disk incorporating a piezoelectric material bonded thereto and operatively coupled to a base rim of a housing provides for closing an open-ended cavity at the first end of the housing. At least one inertial mass is either incorporated in or attached to the housing. A plastic film adhesively bonded to at least one of an outer rim of the housing or an outer-facing surface of the disk provides for receiving an adhesive acoustic interface material to provide for coupling the housing to the skin of a test subject.

Auscultatory sound-or-vibration sensor

An auscultatory sound-or-vibration sensor electronic test signal applied to a sound generator generates an acoustic sound signal, responsive to which an auscultatory sound-or-vibration sensor in proximity to the sound generator generates a corresponding auscultatory sound signal. The auscultatory sound-or-vibration sensor electronic test signal incorporates a plurality of frequency components, each frequency component of which incorporates an integral number of wavelengths and is terminated following a duration of time corresponding to the integral number of wavelengths after that frequency component is applied to the corresponding sound generator. A determination of whether or not the auscultatory sound-or-vibration sensor is functioning properly is made responsive to an analysis of a Fourier Transform of the auscultatory sound signal.

An auscultatory sound signal from at least one auscultatory sound-or-vibration sensor is filtered with a high-pass filter and then segmented into a plurality of associated heart cycle segments responsive to associated R-peak locations of an electrographic envelope signal representing an envelope response to an even power of an associated electrographic signal from an ECG sensor. A representation an envelope responsive to an even power of said auscultatory sound signal within said at least one heart cycle is locally modeled about at least a second peak to provide for locating the start of diastole of said at least one heart cycle.

Medical decision support system

Each conductor of a plurality of insulated conductors of a wiring harness extends between, and electrically connects, a corresponding terminal of a first electrical connector to either a corresponding terminal of an electrical connector jack of a plurality of electrical jacks located along the wiring harness, or to a corresponding terminal of a corresponding auscultatory sound-or-vibration sensor of the plurality of auscultatory sound-or-vibration sensors. The plurality of insulated conductors are organized in a plurality of distinct branches, each distinct branch originating either from the first electrical connector or from another portion of the wiring harness, and the locations of the plurality of distinct branches, in cooperation with the plurality of electrical jacks, if present, are implicitly suggestive of a corresponding location of the corresponding auscultatory sound-or-vibration sensor on a thorax of a test subject.

Wiring harness for use with auscultatory sound-or-vibration sensors

An auscultatory sound signal from at least one auscultatory sound-or-vibration sensor is segmented into a plurality of associated heart cycle segments responsive to associated R-peak locations of an electrographic envelope signal representing an envelope response to an even power of an associated electrographic signal from an ECG sensor. A representation an envelope responsive to an even power of said auscultatory sound signal within said at least one heart cycle is locally modeled about at least a second peak to provide for locating the start of diastole of said at least one heart cycle.

At least one of at least one data-dependent scale factor or at least one data-dependent detection threshold is determined responsive to at least one block of time-series data of an auscultatory-sound signal generated by an auscultatory-sound sensor operatively coupled to a portion of the skin of a test-subject, wherein the at least one data-dependent scale factor or at least one data-dependent detection threshold provides a measure of a range of values of the at least one block of time-series data in relation to a predetermined metric, and is used to determine whether or not the auscultatory-sound sensor is either debonded or detached from the skin of the test-subject.

System and method for detecting decoupling of an auscultatory sound sensor from a test-subject

An auscultatory sound signal acquired by a recording module is coupled through a high-pass filter having a cut-off frequency in the range of 3 to 15 Hz and subsequently filtered with a low-pass filter, and optionally subject to variable-gain amplification under external control&#x2014;via a USB or wireless interface&#x2014;of an associated docking system, responsive to the resulting processed auscultatory sound signal. A sound generator in the docking system generates an associated test signal having an integral number of wavelengths for each of a plurality of frequencies. The test signal is applied to a corresponding auscultatory sound-or-vibration sensor to test the integrity thereof. Resulting sound signals recorded by the recording module are analyzed using a Fourier Transform to determine sensor integrity.

A metallic diaphragm disk incorporating a piezoelectric material bonded thereto and operatively coupled to a base rim of a housing provides for closing an open-ended cavity at the first end of the housing. In one aspect, plastic film adhesively bonded to at least one of an outer rim of the housing or an outer-facing surface of the disk provides for receiving an adhesive acoustic interface material to provide for coupling the housing to the skin of a test subject. In another aspect, an outer-facing surface of a base portion of the housing provides for receiving an adhesive acoustic interface material to provide for coupling the housing to the skin of a test subject, at least one inertial mass is operatively coupled to a central portion of the metallic diaphragm disk, and the opening in the first end of the housing is closed with a cover.

Systems and methods of frequency-domain photoacoustic imaging are provided utilizing an ultrasonic phased array probe and intensity modulated optical excitation with coding to improve signal-to-noise ratio. Embodiments employ frequency-domain photoacoustic imaging methodologies such as the photoacoustic radar, coupled with a multi-element ultrasonic sensor array to deliver spatially-resolved correlation images of photoacoustic sources, which may be employed to image optical heterogeneities within tissue-like scattering media.

Systems and methods for frequency-domain photoacoustic phased array imaging

There is provided a glucose monitoring method and apparatus based on the principle of Wavelength-Modulated Differential Laser Photothermal Radiometry (WM-DPTR). Two intensity modulated laser beams operating in tandem at specific mid-infrared (IR) wavelengths and current-modulated synchronously by two electrical waveforms 180 degrees out-of-phase, are used to interrogate the tissue surface. The laser wavelengths are selected to absorb in the mid infrared range (8.5-10.5 &#x3bc;m) where the glucose spectrum exhibits a discrete absorption band. The differential thermal-wave signal generated by the tissue sample through modulated absorption between two specific wavelengths within the band (for example, the peak at 9.6 and the nearest baseline at 10.5 &#x3bc;m) lead to minute changes in sample temperature and to non-equilibrium blackbody radiation emission. This modulated emission is measured with a broadband infrared detector. The detector is coupled to a lock-in amplifier for signal demodulation. Any glucose concentration increases will be registered as differential photothermal signals above the fully suppressed signal baseline due to increased absorption at the probed peak or near-peak of the band at 9.6 &#x3bc;m at the selected wavelength modulation frequency. The emphasis is on the ability to monitor blood glucose levels in diabetic patients in a non-invasive, non-contacting manner with differential signal generation methods for real-time baseline corrections, a crucial feature toward precise and universal calibration (independent of person-to-person contact, skin, temperature or IR-emission variations) in order to offer accurate absolute glucose concentration readings.

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Ottawa, Canada

Sergey A Telenkov