Segetis, Inc.

Maxygen, Inc.

Codexis Mayflower Holdings, LLC

Codexis, Inc.

Aromagen Corporation

Codexis Mayflower Holding, LLC

Gfbiochemicals Limited

Sergey A Selifonov

Willem P C Stemmer

Jeremy S Minshull

Phillip A Patten

Claes Gustafsson

Stephen B Del Cardayre

Matthew B Tobin

Lorraine Joan Giver

Douglas Wicks

Brian Daniel Mullen

Ning Zhou

Vivek Badarinarayana

Marc Davis Scholten

Charles Todd Williams

Adam Edward Goetz

Scott D Rothstein

Feng Jing

Joseph A Affholter

S Christopher Davis

Tara Jane Mullen

Chunyong Wu

Jason D Pratt

Adam E Goetz

Tara J Mullen

The present disclosure relates to the preparation of acrylate, alkacrylate, allyl, and polycarbonate derivatives of hydroxy ketal esters, and uses thereof.

Ketal ester derivatives

Disclosed herein are ketal amide compounds. The ketal amide compounds are synthesized by the reaction of ketal acids or ketal esters with amine functional compounds. Also disclosed are methodologies useful to make the ketal amide compounds. Also disclosed herein are formulations and articles containing the ketal amide compounds.

Ketal amide compounds, methods of making, and applications

The present disclosure relates to the preparation of ketal compounds from glycerol and levulinic acid and esters, and uses thereof, in particular the manufacture of polyurethanes.

Glycerol levulinate ketals and their use in the manufacture of polyurethanes, and polyurethanes formed therefrom

A ketal ester of an oxocarboxylic acid and a process to make the same, where the ketal ester is of Structure (I): wherein a is 0 or an integer from 1 to 12; n is 0 or 1; Ris a linear alkyl, aryl, arylalkylene, or branched alkyl group with 1-18 carbon atoms; Rand Rcan be hydrogen, Cstraight chain or branched alkyl, phenyl, substituted phenyl, C1-6 alkyl substituted with up to four OH groups, C1-6 alkyl, or acetyl optionally substituted hydrocarbon radicals, or Rand Rtogether with the &#x3b1;-carbon form a cycloaliphatic or heterocyclic ring with 3-6 carbon atoms and 0-3 heteroatoms, provided that only one of Rand Ris hydrogen; Ris a linear alkyl or branched alkyl group with 1-18 carbon atoms; and Ris hydrogen, or an alkyl, aryl, aralkyl or branched alkyl group with 1-10 carbon atoms. 

Ketal esters of oxocarboxylic acids and process of making

The present disclosure relates to methods of preparation of compounds resulting from the reaction of levulinic esters and epoxidized unsaturated fatty acid esters. The compounds are useful as renewable biomass-based plasticizers for a variety of polymers. Mono-, di- and tri-ketal adducts formed in a reaction between alkyl esters of levulinate and epoxidized unsaturated fatty acid esters derived from vegetable oils are also disclosed.

Adducts of levulinic derivatives with epoxidized fatty acid esters and uses thereof

Ketal compounds of the structure I and a method of preparation of the compound from polyols and oxocarboxylates, as well as uses thereof.

Transketalized compositions, synthesis, and applications

Novel ketal compounds can be made from an oxocarboxylate and a triol. Novel polymeric structures are, in turn, synthesized from the ketal compounds. Such ketal compounds and associated polymers are useful in a broad range of applications as a substitute for materials derived from petroleum or other such nonrenewable resources.

Ketal compounds from polyols and oxocarboxylates

The reaction of alcohols with oxocarboxylates to form acetals or ketals is catalyzed by unexpectedly low levels of protic acids. By employing low acid catalyst levels compared to amounts conventionally used, rapid formation of acetal or ketal is facilitated while the formation of oxocarboxylate esters is minimized. Further employing a significant molar excess of oxocarboxylate in conjunction with low acid catalyst level gives rise to the rapid and clean formation of acetals and ketals from oxocarboxylates and alcohols.

Method of making ketals and acetals

In particular, this invention provides novel methods of populating data structures for use in evolutionary modeling. In particular, this invention provides methods of populating a data structure with a plurality of character strings. The methods involve encoding two or more biological molecules into character strings to provide a collection of two or more different initial character strings; selecting at least two substrings from the pool of character strings; concatenating the substrings to form one or more product strings about the same length as one or more of the initial character strings; adding the product strings to a collection of strings; and optionally repeating this process using one or more of the product strings as an initial string in the collection of initial character strings.

Methods of populating data structures for use in evolutionary simulations

Glyceryl ether compounds prepared by the reaction of glycerol and olefin epoxides are disclosed. The compounds are renewable biomass-based surfactants useful as detergents and emulsifiers in formulations for cleaning, laundry, personal care, cosmetics, and industrial uses.

Glyceryl ether compounds and their use

The invention relates to polyketal compounds. The compounds are synthesized by the selective ketalization of oxocarboxylic acids, e.g. keto acids and semialdehydes, and esters thereof with tetrols and higher polyols that products two or more cyclic ketal ester moieties per molecule, wherein the cyclic ketal moieties are situated in a bis-, tris-, or polyketal conformation. The invention further relates to applications of these compounds and subsequent reactions thereof.

Growing community of inventors

Los Altos, CA, United States of America

Sergey A Selifonov