Dnae Group Holdings Limited

Nanodx, Inc.

Other

Alphavax, Incorporated

Dna Electronics Limited

Nanomr, Inc.

Sergey A Dryga

Lisa-Jo Ann Clarizia

Victor C Esch

Eddie W Adams

David Bastable

Farhad Khosravi

Ravil A Sitdikov

Thearith H Ung

Thomas W Dubensky, Jr

Jonathan F Smith

John M Polo

Kurt Iver Kamrud

Sondra Schlesinger

Barbara A Belli

Ian Caley

Ilya V Frolov

Andrew Frederick McDowell

Colin W Dykes

Richard G Saul

Meghan E Norvell

Robert A Olmsted

Maureen Maughan

Jonathan O Rayner

Maureen F Maughan

Robert E Johnston

Nancy L Davis

Jon O Rayner

Ronald I Swanstrom

Elizabeth A Reap

Paula M Keith

Magdalena A Torrance

David K Aley

Erik J Smith

James H Macemon

Ilva Frolov

Jonathon D McMillan

Jeffrey D Chulay

John S Morris

Harold Alterson

Kim Butler

Ian J Caley

Alexandra Barr

Jaclyn Vandervest

Kim Alterson

Andrew F Mcdowell

Sensors having an advantageous design and methods for fabricating such sensors are generally provided. Some sensors described herein comprise pairs of electrodes having radial symmetry, pairs of nested electrodes, and/or nanowires. Some embodiments relate to fabricating electrodes by methods in which nanowires are deposited from a fluid contacted with a substrate in a manner such that it evaporates and is replenished.

Sensor system and methods of making

Systems, devices, and methods of sensing electrical characteristics of a sensor are generally provided. Measurement devices described herein employ techniques for improved sensitivity when sensing electrical characteristics of a sensor. In some aspects, measurement devices described herein may be configured to reduce the impact of current noise generated in components of a measurement system when sensing electrical characteristics of the sensor. The techniques described herein may facilitate the inclusion of larger sense resistors in measurement devices, which increases the sensitivity of the system. In some aspects, such techniques may also facilitate coupling the sensor between the measurement device and ground when sensing the electrical characteristics for improved protection against overvoltage events such as electrostatic discharge (ESD).

Measurement systems and associated techniques for sensing electrical characteristics of a sensor

Sensor system and electrodes

Sensor system and methods

The present invention generally relates to methods of generating antibodies against a species of pathogen that involve identifying the pathogen that is most genetically representative of member of pathogen species and using the identified pathogen to generate an antibody.

Methods for raising antibodies

Sensors having an advantageous design and methods for fabricating such sensors are generally provided. Some sensors described herein have pairs of electrodes having radial symmetry, pairs of nested electrodes, and/or nanowires. Some embodiments relate to fabricating electrodes by methods in which nanowires are deposited from a fluid contacted with a substrate in a manner such that it evaporates and is replenished.

The invention generally relates to using magnetic particles and magnets to isolate a target analyte from a body fluid sample. In certain embodiments, methods of the invention involve introducing magnetic particles including a target-specific binding moiety to a body fluid sample in order to create a mixture, incubating the mixture to allow the particles to bind to a target, applying a magnetic field to capture target/magnetic particle complexes on a surface, and washing with a wash solution that reduces particle aggregation, thereby isolating target/magnetic particle complexes.

Isolating a target analyte from a body fluid

The invention generally relates to using magnetic particles and alternating magnet fields to separate a target analyte from a sample. In certain embodiments, methods of the invention involve contacting a sample with magnetic particles including first moieties specific for a target analyte, thereby forming target/particle complexes in the sample, flowing the sample through a channel including second moieties attached to at least one surface of the channel, applying alternating magnetic fields to the flowing sample to result in target/particle complexes being brought into proximity of the surface to bind the second moieties and unbound particles remaining free in the sample, binding the target/particle complexes to the second moieties, and washing away unbound particles and unbound analytes of the sample.

Separating target analytes using alternating magnetic fields

The invention generally relates to conducting an assay on a sample that isolates a pathogen from the sample and allows for analysis of the pathogen with minimal (i.e., at most 24 hrs of culturing) or no culturing of the pathogen. In certain embodiments, the invention provides methods for identifying a pathogen from a sample that involve obtaining a sample including a pathogen, conducting an assay that isolates the pathogen from the sample, culturing the isolated pathogen for at most about 24 hrs, and analyzing the pathogen.

Analyzing bacteria without culturing

The invention generally relates to methods of using compositions that include sets of magnetic particles, members of each set being conjugated to an antibody specific for a pathogen, and magnets to isolate a pathogen from a body fluid sample.

Methods for isolating a target analyte from a heterogenous sample

Growing community of inventors

Albuquerque, NM, United States of America

Sergey A Dryga