Novartis Vaccines & Diagnostics, Gmbh

Sergey A Drvga

Thomas W Dubensky, Jr

John M Polo

Ilya V Frolov

Sondra Schlesinger

Barbara A Belli

Isolated nucleic acid molecules are disclosed, comprising an alphavirus nonstructural protein gene which, when operably incorporated into a recombinant alphavirus particle, eukaryotic layered vector initiation system, or RNA vector replicon, has a reduced level of vector-specific RNA synthesis, as compared to wild-type, and the same or greater level of proteins encoded by RNA transcribed from the viral junction region promoter, as compared to a wild-type recombinant alphavirus particle. Also disclosed are RNA vector replicons, alphavirus vector constructs, and eukaryotic layered vector initiation systems which contain the above-identified nucleic acid molecules.

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Fort Collins, CO, United States of America

Sergey A Drvga