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Federalnoe Gosudarstvennoe Unitarnoe Predpriyatie “Gosudarstvenny Nauchny Tsentr Nauchno-Issledovatelsky Institut Organicheskikh Poluproduktov I Krasitelei” (Fgup “Gntts Niopik”)

Gosudarstevennoe Obrazovatelnoe Uchrezhdenie Vysshego Professionalnogo Obrazovaniya Moskovskaya Meditsinskaya Akademiya Im. I.m. Sechenova Rf (gouvpo Mma Im. I.m. Sechenova Mz Rf)

Sergei Vitalievich Grachev

Georgy Nikolaevich Vorozhtsov

Oleg Leonidovich Kalia

Natalya Ivanovna Kazachkina

Nikolai Pavlovich Kozlov

Yury Mikhailovich Luzhkov

Evgeny Antonovich Lukyanets

Eduard Izrailevich Galperin

Anatoly Borukhovich Shekhter

Roman Sergeevich Goloschapov

Andrei Borisovich Vagapov

Tatyana Gennadievna Dyuzheva

Aleksandr Valerievich Pekshev

Vadim Romanovich Nakhamiyaev

A method and apparatus for forming NO-containing gas flow to treat a biologic object are disclosed. The NO-containing gas flow is formed from a source gas comprising at least oxygen and nitrogen in a housing () comprising at least two electrodes () insulated from each other, a stationary dc arc discharge being generated and maintained between the electrodes. The NO-containing gas flow is formed from the source gas in the area between the electrodes () under the effect of the arc discharge and withdrawn through a cooled channel, enabling nitrogen oxide to be fixed in the flow and the temperature of the flow and the NO content therein to be brought to values required to provide efficient therapy of a biologic object.

Method and device for forming an no-containing gas flow for affecting a biological object

A method for regional administration of preparations during the therapy of liver tumor, comprising administering a preparation into a branch of the portal vein with the simultaneous occlusion of afferent and efferent lobe vessels (branches of the portal vein proximal the place of puncture, branches of the hepatic artery and lobar hepatic vein) for 5&#x2013;15 minutes. During catalytic therapy, it is preferable to use Teraphtalum as the preparation and to administer ascorbic acid after termination of occlusion. During photodynamic therapy, it is preferable to use photosens as the preparation and to carry out irradiation of the tumor after 10&#x2013;35 minutes. This method of administration provides for the predominant accumulation of the preparations in the target lobe (tumor carrier lobe) of the liver, their low penetration into the systemic blood flow, which makes it possible to reduce the dose of the preparation and its general toxicity.

Method for therapy of liver tumors

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Moscow, Russia

Sergei Vitalievich Grachev