Staar Surgical Ag

Other

Staar Surgical Company, Inc.

Sergei Nikolayevich Bagrov

Svyatoslav N Fedorov

Yevgeny Viktorovich Larionov

Vladimir Borisovich Malyshev

Alexei V Osipov

Irina A Maklakova

Tatyana S Amstislavskaya

Albina Ivanovna Ivashina

Sergei Viktorovich Novikov

Galina Dmitriyevna Shelukhina

Irina Aleksandrovna Maklakova

Evgeny V Larionov

Alexei N Kosmynin

Elena A Linnik

Vladislav T Trofimov

Victor Konstantinovich Zuev

Niaz Fuadovich Saifullin

Aleksandr Aleksandrovich Karavaev

A biological material is prepared for use in ophthalmology by steps of providing animal pericardium, subjecting the animal pericardium to multiple steps of freezing and thawing in a salt solution and incubating the animal pericardium in a solution of ammonia and ethyl alcohol. The multiple steps of freezing and thawing are conducted in a mixture of about 0.9% sodium chloride solution and distilled water in about 1:1 proportions of sodium chloride solution to distilled water. The incubating step is conducted in a mixture of 1% ammonia solution and 1% ethyl alcohol solution in about 1:1 proportions of ammonia solution to ethyl alcohol solution over a period of 48 to 72 hours.

Biological material, method of preparing such materials

Biological material, method of preparing such materials, uses thereof

A collagen containing substrate comprising cattle basal membrane is conditioned by incubating the membranes in a mixture of pepsin, hyaluronidase and acetic acid and separating the collagen from the mixture. The mixture can include pepsin, hyaluronidase and a 0.5M solution of acetic acid in 1:1:10 proportions. The incubation is conducted for about 10 hours at about 45.degree. C. After incubation, collagen is separated from the mixture by centrifuging at a speed of 5000 to 30000 rpms for about 30 minutes. The collagen is mixed with polymerizable monomer and polymerized to form a gel that can be ground to form an intraocular or contact lens.

Method of preparing a biological material for use in ophthalmology

The present invention is directed to a biocompatible polymeric material and methods of making prepared by forming a mixture of collagen, a water-soluble ethylenically unsaturated compound and a cross-linking agent at a temperature of 30.degree. C. to 42.degree. C.; adjusting the pH of the mixture to 3.2 to 5.0; and polymerizing the mixture. The resulting material is rinsed in a physiologic solution at a temperature of 25.degree. C. to 80.degree. C. The resulting polymeric material has a modules of elasticity in the range of 10 to 27.times.10.sup.5 N/m.sup.2. Mechanical strength of the polymeric material is 20 to 100 times greater than polymeric material prepared by known methods. The material is optically transparent and is characterized by 95% or more light transmission in the visible spectrum and by resolution of 200 lines per mm for a +20D intraocular lens. The material is characterized by low protein absorption of about 0.1.times.10.sup.-3 .mu.g/mg and the material is resistant to proteolytic enzymes including pepsin, trypsin, chymotrypsin, and collagenase. The present invention is further directed to intraocular lenses and contact lenses produced from the present material, and the use of such lenses in patients having impaired vision to correct or improve such impaired vision.

Biocompatible polymeric materials, methods of preparing such materials

A collagen containing substrate comprising cattle basal membrane is conditioned by incubating the membranes in a mixture of pepsin, hyaluronidase and acetic acid and separating the collagen from the mixture. The mixture can include pepsin, hyaluronidase and a 0.5 M solution of acetic acid in 1:1:10 proportions. The incubation is conducted for about 10 hours at about 45.degree. C. After incubation, collagen is separated from the mixture by centrifuging at a speed of 5000 to 30000 rpms for about 30 minutes. The collagen is mixed with polymerizable monomer and polymerized to form a gel that can be ground to form an intraocular or contact lens.

The present intraocular lens includes a body portion and an optic portion. A thickness of the body portion is between 0.3 to 0.98% of a thickness of the intraocular lens itself which lens includes the body portion and the optic portion, and from 0.011 and 0.015% of a length of the body portion. The thickness of the intraocular lens itself, from 0.095 and 0.192% of the length of the body portion. The diameter of the optic portion is from 0.153 and 0.7% of the length of the body portion. The optic portion can have an anterior surface having a radius of curvature of from 0.29 and 0.967% of the radius of curvature of the posterior surface of said intraocular lens. The lens is implanted by insertion into the posterior chamber of the eye to a position anterior to the natural crystalline lens of the eye. The implanted lens is effective in correcting moderate to severe forms of hypermetropia.

Intraocular lens for correcting moderate to severe hypermetropia

A biocompatible material which is the product of graft-copolymerization of a water-soluble vinyl and/or an acrylate monomer with a sorption complex of polysilicic acid and collagen that has been rid of pigments, glycoproteins and proteoglycans, or a product obtained by virtue of chemical destruction, with the aid of hydrofluoric acid, of the afore-mentioned product of graft-copolymerization, containing up to 25 mass percent of polysilicic acid (in terms of SiO.sub.2), up to 12 mass percent of protein, and maximum 1 10.sup.-6 mole/g of an anion of hydrofluoric and hydrofluoric acids, methods of making the same and products produced thereby.

Biocompatible polymer material and a process for producing same

A process for producing a collagen-based cross-linked biopolymer is provided in which a collagen solution free of low-molecular impurities is saturated with nitrogen protoxide, its concentration is brought to maximum 80 mass percent and the solution is exposed to an ionizing radiation in a dose of 0.5 to 15 kGy. An implant for hermetization of corneal and scleral wounds involved in eye injuries prepared from said bipolymer has the shape and size that provide for complete hermetization of said wounds. The method for its preparation comprises saturation of a collagen solution free of impurities and having a concentration of 0.2 to 1.3 mass percent, with nitrous oxide, filling of a mould with said solution and its exposure to an ionizing radiation in a dose of 0.5 to 15 kGy. The resultant blank is dried to a moisture content in its biopolymer of 30 to 50 mass percent, whereupon the blank is given the shape and size of a required implant. The method of hermetization of said wounds is carried into effect by introducing the implant shaped as a cylinder with a tapered end, with said end into an operative wound incision, fixing the implant in the wound for 1 or 2 minutes and removal of the implant portion that stands over the corneal or scleral surface.

Process for producing collagen-based cross-linked biopolymer, an implant

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Moscow, Russia

Sergei Nikolayevich Bagrov