Beckman Coulter, Inc.

University Health Network

Sergei Gulnik

Arunkumar Easwaran

Massimiliano Tomasulo

Lidice L Lopez

David Hedley

T Vincent Shankey

Sue Chow

George C Brittain, Iv

George C Brittain

George Brittain

George C Iv Brittain

David W Hedley

The present invention provides water soluble photoactive macromolecular complexes and methods for detecting an analyte in a sample by using a binding agent conjugated to a water soluble photoactive macromolecule.

Photoactive macromolecules and uses thereof

Water-soluble photoactive polymers, included polymer tandem dyes, as described as well as methods for their preparation and use. The photoactive polymers can be prepared by direct modification of core polymers (e.g., violet excitable polymers) with dyes or other functional groups. Methods of detecting analytes using the polymers are also described.

Polymer dye modification and applications

This disclosure provides methods and kits for lysing red blood cells from whole blood.

Compositions and methods for lysis of red blood cells

Assays that can measure the effect of proteasome inhibitors on target cells in a biological sample are provided. The assays include evaluation of the effects of proteasome inhibitors on proteasome activity in cells in a biological sample.

Proteasome inhibition assay and methods of use

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Miami, FL, United States of America

Sergei Gulnik