Glycomimetics, Inc.

Other

The United States of America, As Represented by the Secretary, Department of Health and Human Services

Advanced Tear Diagnostics, Llc.

The State University of New York

Sergei A Svarovsky

John L Magnani

Arun K Sarkar

Beat Ernst

John Tinsman Patton, Jr

Bruce E Cohen

Kate Rittenhouse-Olson

Joseph John Barchi, Jr

Andrew Douglas Penman

Sergey V Sheleg

Hugh LeRoy Hixon, Jr

Catalina Valencia

Marcus Willard Smith

Joseph J Barchi

Jr Joseph J Barchi

The presence of biomarkers or other analytes can be detected in the bodily fluid using Electrochemical Impedance Spectroscopy (EIS) or Electrochemical Capacitance Spectroscopy (ECS) in devices, such as handheld point-of-care devices. The devices, as well as systems and methods, utilize using Electrochemical Impedance Spectroscopy (EIS) or Electrochemical Capacitance Spectroscopy (EIS) in combination with an antibody or other target-capturing molecule on a working electrode. Imaginary impedance or phase shift, as well as background subtraction, also may be utilized.

Point-of-care apparatus and methods for detecting cancer using electrochemical impedance or capacitance spectroscopy

Compounds and methods are provided for modulating in vitro and in vivo processes mediated by selectin binding. More specifically, selectin modulators and their use are described, wherein the selectin modulators that modulate (e.g., inhibit or enhance) a selectin-mediated function comprise particular glycomimetics alone or linked to a member of a class of compounds termed BASAs (Benzyl Amino Sulfonic Acids) or a member of a class of compounds termed BACAs (Benzyl Amino Carboxylic Acids).

Heterobifunctional pan-selectin inhibitors

A method for hypothermic preservation of biological tissue for later recovery to a viable state includes flushing the biological tissue with a gas mixture of sulfur hexafluoride or xenon and oxygen. The sulfur hexafluoride or xenon is in a concentration in the mixture between about 75 mole percent to 95 mole percent. The method includes pressurizing the biological tissue, preferably isothermically, with the mixture to a pressure that will form clathrates inside the biological tissue at a desired storage temperature in a range of about +1&#xb0; C. to about +5&#xb0; C. The method includes a step of cooling the biological tissue, preferably isobarically, to the desired storage temperature. Optional steps for further cooling to no colder than about &#x2212;20&#xb0; C. and for depressurization are provided as well as steps for recovering the hypothermically preserved biological tissue to a viable state, preferably using a recovery gas mixture.

Hypothermic preservation of biological tissues and cells

Novel biofunctionalized quantum dots include a mercaptoalkanoic acid linked to the surface of a nanocrystalline core and a bio-functional group linked to the surface. Biofunctionalized quantum dots are made by a novel synthesis method. Biofunctionalized quantum dots can be used in imaging or therapy applications.

Biofunctionalized quantum dots for biological imaging

Growing community of inventors

North Potomac, MD, United States of America

Sergei A Svarovsky