Universiteit Gent

Vib Vzw

Universiteit Antwerpen

La Jolla Institute for Allergy and Immunology

University of Gent

Serge Van Calenbergh

Dirk Elewaut

Hassan Jomaa

Jochen Wiesner

Wim Vanden Berghe

Guy Haegeman

Karolien De Bosscher

Carl Jeffrey Lacey

Gilles Brackman

Timothy Haemers

Vincent Devreux

Guy Caljon

Joren Guillaume

Arno Vermote

Tom Coenye

Dirk Zajonc

Martijn Risseeuw

Fabian Hulpia

Louis Maes

Nora Pauwels

Sandrine Aspeslagh

The present invention relates to novel nucleoside analogues and compositions containing said nucleoside analogues. Moreover, the present invention provides processes for the preparation of the disclosed compounds, as well as methods of using them, for instance as a medicine, in particular for the diagnosis, prevention and/or treatment of parasitic infections, more specifically for use in the diagnosis, prevention and/or treatment of ainfection.

Nucleoside analogues for the treatment of parasitic infections

The compounds, compositions and methods provided herein antagonize, inhibit, decrease, reduce, suppress, or disrupt CD1d-mediated, iNKT cell-mediated, and/or iNKT cell TCR-mediated immune signaling. The sphingamide compounds were rationally designed based upon 3D structural considerations in relation to the structures of each of CD1d, the iNKT cell TCR, and the ternary complex CD1d-a-GalCer analog lipids-TCR. More specifically, the addition of an amide in the phytosphingosine tail of a derivative of &#x3b1;-GalCer led to a non-conserved binding with CD1d, a conserved binding with the iNKT cell TCR, and an antagonist-like phenotype.

Sphingamide compounds and methods for binding iNKT cells

The present invention relates to hamamelitannin analogues, pharmaceutical compositions comprising the same, and combinations thereof with anti-microbial agents such as antibiotics or disinfectants. It in particular relates to the use of the compounds, compositions and combinations according to this invention in human or veterinary medicine, more in particular for use in the prevention and/or treatment of bacterial infections, such asinfections, in humans or animals. 

Hamamelitannin analogues and uses thereof

This invention relates to carbamate-containing or thiocarbamate-containing galacto-pyranosyl compounds useful as therapeutic agents and being represented by the structural formula (II), wherein: X is O or S, R is selected from the group consisting of Calkyl, Ccycloalkyl, aryl-Calkyl, heterocyclyl-Calkyl, cycloalkyl-Calkyl, aryl and heterocyclyl, wherein R is optionally substituted with one or more R; R, R, R, Rand Rare independently selected from the group consisting of hydroxyl and protected hydroxyl groups; Ris selected from the group consisting Calkyl and arylalkyl; Ris Calkyl; and each Ris independently selected from the group consisting of halogen, hydroxy, trifluoromethyl, trifluoromethoxy, Calkoxy, Calkyl, cyano, methylthio, phenyl, phenoxy, chloromethyl, dichloromethyl, chloro-difluoromethyl, acetyl, nitro, benzyl, heterocyclyl and di-Calkyl-amino, or a pharmaceutically acceptable salt thereof. 

Galactopyranosyl derivatives useful as medicaments

This invention provides compounds having the structural formula: wherein:

Synephrine derivatives useful as anti-inflammatory agents

The present invention relates to novel phosphonic acid compounds having the structural formula (I): wherein: (a) R is a group of 1 to 5 substituents independently selected from the group consisting of fluoro, chloro, bromo, Calkoxy, Calkyl, hydroxy, formyl, trifluoromethoxy, phenyl, heterocyclic, heterocyclic-substituted methyl, aminomethyl, hydroxy methyl, bromomethyl, sulfonyl chloride, acetyl chloride, nitroso and cyano, (b) Ris selected from the group consisting of hydrogen, Calkyl, Ccycloalkyl, aryl, arylalkyl and heterocyclic, and (c) Ris selected from the group consisting of hydroxy and hydroxy-protecting groups, and stereoisomer, solvates and salts thereof. These compounds are useful as anti-infectious and anti-parasitic agents, in particular anti-malaria agents.

Organophosphoric derivatives useful as anti-parasitic agents

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De Pinte, Belgium

Serge Van Calenbergh