Boehringer Ingelheim International Gmbh

Gilead Sciences, Inc.

Boehringer Ingelheim (canada) Ltd.

Boehringer Ingelheim Gmbh

Serge R Landry

Bruno Simoneau

Sebastien Morin

Christiane Yoakim

Youla S Tsantrizos

Jeffrey O'Meara

Bounkham Thavonekham

Lee Fader

Stephen Kawai

Rebekah J Carson

Murray D Bailey

Teddy Halmos

Anne-Marie Faucher

Mathieu Parisien

Marc-Andre Poupart

Francois Bilodeau

Alexandre Gagnon

Patrick Deroy

Rene Coulombe

Steven LaPlante

Jean Rancourt

Gulrez Fazal

Marc-André Poupart

Christian Brochu

Julie Naud

Eric Malenfant

Josee Bordeleau

Steven Laplantea

Steve Mason

François Bilodeau

René Coulombe

Sébastien Morin

Jeffrey O'MEARA

Josée Bordeleau

Compounds of formula I: wherein R, Rand Rare defined herein, are useful as inhibitors of HIV replication.

Inhibitors of human immunodeficiency virus replication

Compounds of formula I: wherein c, R, R, R, R, R, Rand Rare defined herein, are useful as inhibitors of HIV replication. 

Compounds of formula (I): wherein Ar, X, R, R, Rand Rare as defined herein. The compounds are useful as reverse transcriptase inhibitors against wild type and single or double mutant strains of HIV.

Non-nucleoside reverse transcriptase inhibitors

The present invention relates to compounds of formula (I) wherein c, X, Y, R, R, Rand Rare as defined herein, compositions and uses thereof for treating human immunodeficiency virus (HIV) infection. In particular, the present invention provides novel inhibitors of HIV integrase, pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HIV infection.

Disclosed herein are compounds of formula Ar&#x2014;X&#x2014;W&#x2014;Arwherein Arand Arrepresent aryl groups characterized generally as aromatic heterocycles (e.g. imidazolyl or tetrazolyl) or carbocycles (e.g. phenyl or naphthalenyl); the aryl groups are optionally substituted or fused with other heterocycles or carbocycles; the aryl groups can bear substituents such as alkyl, halo or O-alkyl. X is a heteroatom, a valence bond or an optionally substituted divalent methylene, and W represents a spacer; typical spacers include divalent alkylene or alkylene-amido, -amido or -oxy radicals, which may optionally be substituted (e.g. hydroxyl or oxo). A typical compound is a derivative of 2-(N-napthalenyltetrazolylthio)-N-(2-nitrophenyl)acetamide. The compounds have inhibitory activity against Wild Type and single or double mutant strains of HIV.

Non nucleoside reverse transcriptase inhibitors

Compounds or enantiomers of formula (I) or a salt thereof: wherein R, R, R, Rand Rare as defined herein, are useful for the manufacture of a medicament for the treatment or prevention of respiratory syncytial virus infection in a mammal.

RSV polymerase inhibitors

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St-Jerome, Canada

Serge R Landry