Centre National De La Recherche Scientifique

Universite Claude Bernard – Lyon1

Hospices Civils De Lyon

Laboratoires Hoechst S/a

Serge Petit

Jean-Jacques Diaz

Jacques Dreux

Jean-Christophe Saurin

Jean-Xavier Roca-Martinez

The invention relates to antibodies specific to human CK8 and to pharmaceutical compositions for preventing and treating colorectal cancers. The invention also relates to methods for identifying colorectal cancers with an invasive and/or metastatic phenotype including detecting the cleavage of the C-terminal portion of human CK8 on the surface of tumor cells.

Anti-CK8 antibodies to be used for treating colorectal cancers and identifying metastatic and/or invasive phenotypes

New drugs comprising 2,3- or 3,4-diphenyl derivatives of .gamma.-nitrile-esters or the products of cyclization of the 2,3-diphenyl derivatives according to the formulae A, B and C are claimed. Process for cyclization of 2,3-diphenyl derivatives of .gamma.-nitrile-esters, new 2,3-diphenyl derivatives of .gamma.-nitrile-esters corresponding to the formulae I to VIII are claimed; new 3,4-diphenyl derivatives of the said esters coresponding to the formulae IX and X, and new 3,4-diphenylpiperidone derivatives corresponding to the specific formulae IX to XXVII are described.

Drugs comprising 2,3- or 3,4-diphenyl derivatives of

Growing community of inventors

Villeurbanne, France

Serge Petit