Creative Biomolecules, Inc.

Serge N Timasheff

Hermann Oppermann

James S Huston

Disclosed are serine-rich peptide linkers for linking two or more protein domains to form a fused protein. The peptide linkers contains at least 40% serine residues and preferably have the formula (Ser, Ser,Ser,Ser,Gly).sub.y where y is .gtoreq.1. The resulting fused domains are biologically active together or individually, have improved solubility in physiological media, and improved resistance to proteolysis.

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Wellesley Hills, MA, United States of America

Serge N Timasheff