Sanofi-aventis

Sanofi

Sanofi-synthelabo

Elf Sanofi

Serge Martinez

Francis Barth

Christian Congy

Murielle Rinaldi-Carmona

Murielle Rinaldi

Pierre Casellas

Vincenzo Proietto

Didier Van Broeck

Philippe Pointeau

Xavier Emonds-Alt

Laurent Hortala

Gilles Anne-Archard

Pascale Roux

Philippe Camus

Martine Vernhet

Xavier Edmonds-Alt

Martine Artiaga

Joelle Arnaud

Joëlle Arnaud

The present invention relates to compounds corresponding to formula (I) in which: &#x2014;Rrepresents a substituted phenyl; &#x2014;Rrepresents: &#x2014;a substituted phenyl; &#x2014;a heteroaromatic group, the said group being unsubstituted or substituted one or more times; &#x2014;Rrepresents a group Alk; &#x2014;Rrepresents a hydrogen atom or a (C-C)alkyl; &#x2014;Rrepresents a hydrogen atom, a (C-C)cycloalkyl or a (C-C)alkyl-O-Alk; &#x2014;or alternatively Rand R, together with the nitrogen atom to which they are attached, constitute a heterocyclic radical chosen from: azetidin-1-yl, pyrrolidin-1-yl, piperid-1-yl, morpholin-4-yl; &#x2014;Rrepresents a group &#x2014;COOAlk, a group &#x2014;CONHor a group &#x2014;NHSOAlk; &#x2014;Alk represents a (C-C)alkyl, which is unsubstituted or substituted one or more times with a halogen atom; in the form of the base or of an acid-addition salt. Preparation process and diagnostic and therapeutic use. 

1,3,5-triazine-2-amine derivatives, preparation thereof and diagnostic and therapeutic use thereof

The present invention relates to compounds corresponding to formula (I): Wherein X, R, R, Rand Rare as defined herein. The invention further relates to preparation and therapeutic use of these compounds.

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The present invention relates to compounds corresponding to the formula (I): In which R, R, R, Rand Rare as described herein. The invention also relates to the method of preparation of said compounds and their application in therapeutics.

Derivatives of N-[(1,5-diphenyl-1H-pyrazol-3-yl)methyl] sulfonamide, their preparation and their application in therapeutics

The invention relates to 4-cyanopyrazole-3-carboxamide derivatives of formula (I): in which R, R, R, R, R, R, R, Rare as described herein. Also disclosed and claimed are the method of preparation and therapeutic application of compound of formula (I).

4-cyanopyrazole-3-carboxamide derivatives, preparation and application thereof

The invention relates to terphenyl derivatives of formula: and to their preparation and to the pharmaceutical compositions comprising them. These compounds exhibit an antagonist activity with respect to CBcannabinoid receptors.

Terphenyl derivatives, preparation thereof, compositions containing same

The subject of the invention is tricyclic derivatives of pyrazolecarboxylic acid of formula: in which Rrepresents a C-Ccarboxyl radical or an NRRgroup. The invention also relates to the method for preparing the compounds of formula (I), pharmaceutical compositions containing them. The compounds of formula (I) are active on cannabinoid CBreceptors.

Pyrazolecarboxylic acid tricyclic derivatives, preparation and pharmaceutical compositions containing same

Derivatives of N-[(1,5-diphenyl-1H-pyrazol-3-yl)methyl]sulfonamide, their preparation and their application in therapeutics

The invention relates to compounds of formula (I): Wherein R, R, R, R, R, R, R, R, Rare as defined herein. The invention also relates to the preparation method thereof and to the use of same in therapeutics.

Derivatives of N'-(1,5-diphenyl-1H-pyrazol-3-yl) sulfonamide with CB1 receptor affinity

4-cyanopyrazole-3-carboxamide derivatives, preparation, and application thereof

The subject of the invention is tricyclic derivatives of pyrazolecarboxylic acid of formula:in which Rrepresents a C-Ccarboxyl radical or an NRRgroup. The invention also relates to the method for preparing the compounds of formula (I), pharmaceutical compositions containing them. The compounds of formula (I) are active on cannabinoid CBreceptors.

N-Piperidino-5-(4-bromophenyl)-1-(2,4-dichlorophenyl)-4-ethylpyrazole-3-carboxamide and its salts and solvates are powerful antagonists of the CB cannabinoid receptors. They are prepared by reacting a functional derivative of 5-(4-bromophenyl)-1-(2,4-dichlorophenyl)-4-ethylpyrazole-3-carboxylic acid with 1-aminopiperidine, optionally followed by salification.

Pyrazolecarboxylic acid derivatives, their preparation, pharmaceutical compositions containing them

Pyrazole derivatives, method for preparing same, and pharmaceutical

The present invention relates to compounds of the formula: ##STR1## These compounds are useful in pharmaceuticals in which cannabis is known to be involved.

Pyrazole derivatives, method of preparing them and pharmaceutical

The invention relates to N-alkylenepiperidino compounds of formula ##STR1## as well as their enantiomers, a process for preparing them and pharmaceutical compositions containing them. These compounds are useful as antagonists of neurokinin receptors in the treatment of substance P- and/or neurokinin-dependent pathologies.

Process for preparing N-alkylene piperidino compounds and their

The present invention relates to novel pyrazole-3-carboxamide derivatives of the formula ##STR1## in which the substituents are as defined in the specification. The present invention further relates to a process for the preparation of these novel derivatives and to the pharmaceutical compositions in which they are present.

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Montpellier, France

Serge Martinez