Metabasis Therapeutics, Inc.

Rempex Pharmaceuticals, Inc.

Melinta Subsidiary Corp.

Viking Therapeutics, Inc.

Gensia, Inc.

Qpex Biopharma, Inc.

Melinta Therapeutics, Inc.

Serge H Boyer

Scott J Hecker

Mark D Erion

Michael N Dudley

David C Griffith

Raja K Reddy

K Raja Reddy

Maxim Totrov

Venkat Reddy Mali

Gavin C Hirst

Olga Rodny

Zhili Sun

William Craigo

Qun Dang

Robert Huerta Lemus

Haiqing Li

Matthew P Grote

Thanh Huu Nguyen

Jorge E Gomez-Galeno

Paul D Van Poelje

Mingwei Chen

Brett C Bookser

Bheemarao G Ugarkar

Nicholas Brian Raffaele

Hongjian Jiang

Jeff Stebbins

Brian Lian

Rochelle Hanley

Misha Dinerman

Olga Lomovskaya

Laurent Lefort

Mali Venkat Reddy

Andreas H M De Vries

Angela Gonzalez De Castro

Petrus J Hermsen

Gerardus K M Verzijl

Hubertus J A Dielemans

Methods useful for treating X-linked adrenoleukodystrophy are provided.

Use of thyroid beta-agonists

Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the use and preparation thereof. Some embodiments relate to cyclic boronic acid ester derivatives and their use as therapeutic agents.

Therapeutic uses of pharmaceutical compositions comprising cyclic boronic acid ester derivatives

Compositions, pharmaceutical compositions, and methods for preparing the same, comprising a tetracycline with improved stability and solubility, are disclosed. Some embodiments include a tetracycline with an excess of a divalent or trivalent cation.

Tetracycline compositions

Disclosed herein are methods for the preparation of boronate derivatives in the synthesis of antimicrobial compounds and uses thereof. Disclosed herein includes method of making a compound of Formula (B) by reducing the ketone group of the keto-ester compound of Formula (A), and the reduction can be performed using a Ruthenium based catalyst system or using an alcohol dehydrogenase bioreduction system.

Synthesis of boronate ester derivatives and uses thereof

The present invention relates to compositions, pharmaceutical compositions, and methods for preparing the same, comprising a tetracycline with improved stability and solubility. Some embodiments include a tetracycline with an excess of a divalent or trivalent cation.

Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the method of use and preparation thereof. Some embodiments relate to boronic acid derivatives and their use as therapeutic agents, for example, &#x3b2;-lactamase inhibitors (BLIs).

Boronic acid derivatives and synthesis thereof

The present invention provides for novel compounds of Formula (I) and pharmaceutically acceptable salts and co-crystals thereof which have glucagon receptor antagonist or inverse agonist activity. The present invention further provides for pharmaceutical compositions comprising the same as well as methods of treating, preventing, delaying the time to onset or reducing the risk for the development or progression of a disease or condition for which one or more glucagon receptor antagonist is indicated, including Type I and II diabetes, insulin resistance and hyperglycemia. The present invention also provides for processes of making the compounds of Formula I, including salts and co-crystals thereof and pharmaceutical compositions comprising the same.

Antagonists of the glucagon receptor

This invention pertains to the use of fused bicycle heterocyclic adducts of thiohydroxy pyridines or pyrimidines as diacylglycerol O-acyltransferase 1 (DGAT-1) inhibitors to treat hyperlipidiemias and various diseases and disorders associated therewith. Other conditions also be ameliorated or avoided, such as high postprandial triglycerides or diet-related hypertriglyceridemia, cardiovascular risk associated with excessive triglycerides, and insulin resistance/glucose intolerance in overweight patients, those with diabetes or other glucose metabolic disorders such as Syndrome X and/or polycystic ovary disease.

Inhibitors of diacylglycerol O-acyltransferase 1 (DGAT-1) and uses thereof

Disclosed herein are boronate intermediates in the synthesis of antimicrobial compounds and the use and preparation thereof. Some embodiments relate to crystalline boronate salt derivatives and their use in the synthesis of therapeutic compounds.

Synthesis of boronate salts and uses thereof

A thyroid hormone receptor agonist and its use in the treatment of a disease associated thyroid hormone receptor beta are described. The compound can be effective in lowering cholesterol with minimum or no adverse effects on the heart or thyroid hormone axis.

Thyroid hormone receptor agonist and use thereof

Growing community of inventors

San Diego, CA, United States of America

Serge H Boyer