Boehringer Ingelheim International Gmbh

Evotec International Gmbh

Forge Therapeutics, Inc.

Blacksmith Medicines, Inc.

Serge Convers-Reignier

Holly Atton

Min Teng

Georg Dahmann

Matthias Hoffmann

Gerhard Schaenzle

David Thomas Puerta

Xiaoming Li

Stephen East

John Scott

Jasna Klicic

Clive Mccarthy

Daniel Bischoff

Baskar Nammalwar

Ian Yule

Stefan Ludwig Michael Wollin

Frederic Jacques Marlin

Alastair Parkes

Christian Perez

Michelle Southey

Adele Faulkner

Christopher John Brown

Christopher Francis Palmer

James Lindsay Carr

Daryl Simon Walter

Jonathan Paul Shine

Scott Alexander Sadler

Mohamad Sabbah

Michael Corr

Marissa Flower

Irena Reboule

Provided herein are heterocyclic derivative compounds and pharmaceutical compositions comprising said compounds that are useful for inhibiting the growth of gram-negative bacteria. Furthermore, the subject compounds and compositions are useful for the treatment of bacterial infection, such as urinary tract infection and the like.

Antibacterial compounds

The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts, solvates, hydrates, tautomers or stereoisomers thereof, wherein R, R, R, R, R, R, R, R, R, X, X, Aand Ahave the meaning as indicated in the description and claims. The invention further relates to pharmaceutical compositions comprising said compounds, their use as medicament and in a method for treating and preventing of one or more diseases or disorders associated with integrated stress response.

Modulators of the integrated stress response pathway

Provided herein are heterocyclic derivative compounds of Formula (II), and pharmaceutical compositions comprising said compounds that are useful for inhibiting the growth of gram-negative bacteria. Furthermore, the subject compounds and compositions are useful for the treatment of bacterial infection, such as urinary tract infection and the like. 

Disclosed are substituted quinolines of formula 1 whereinRand Rare defined herein, the processing of making and using the same.

Substituted quinolines and their use as medicaments

Growing community of inventors

Abingdon, United Kingdom

Serge Convers-Reignier