University of Pittsburgh

Serene Tai

Peter Wipf

Joel Byron Nelson

Zhou Wang

James K Johnson

Erin M Skoda

Keita Takubo

John Milligan

A compound, or a pharmaceutically acceptable salt or ester thereof, according to formula I:R&#x2014;(Z)&#x2014;(Y)&#x2014;(R)&#x2014;(X)&#x2014;R&#x2014;Rwherein Ris aryl, substituted aryl, heteroaryl, substituted heteroaryl, cycloalkyl, substituted cycloalkyl, heterocycloalkyl, substituted heterocycloalkyl, alkoxy, aryloxy, a thio-containing group, or a seleno-containing group; Z is alkanediyl, substituted alkanediyl, cycloalkanediyl, or substituted cycloalkanediyl; Y is S, O, S(&#x2550;O), &#x2014;S(&#x2550;O)(&#x2550;O)&#x2014;, or NR, wherein Ris H or alkyl; Ris alkanediyl, substituted alkanediyl, cycloalkanediyl, substituted cycloalkanediyl, alkadienyl, substituted alkadienyl, cycloalkenediyl, substituted cycloalkenediyl, alkatrienyl, substituted alkatrienyl; X is &#x2014;C(&#x2550;O)&#x2014;, &#x2014;S(&#x2550;O)(&#x2550;O)&#x2014;, or &#x2014;N(H)C(&#x2550;O)&#x2014;; Rincludes at least one divalent amino radical; Ris aryl, substituted aryl, heteroaryl, substituted heteroaryl, cycloalkyl, substituted cycloalkyl, heterocycloalkyl, substituted heterocycloalkyl, alkoxy, aryloxy, a thio-containing group, or a seleno-containing group; a, b, c, and d independently are 0 or 1.

Small molecule inhibitors of the nuclear translocation of androgen receptor for the treatment of castration-resistant prostate cancer

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Pittsburgh, PA, United States of America

Serene Tai