Lucite International Specialty Polymers & Resins Limited

Mitsubishi Chemical Corporation

Lucite International UK Limited

Lucite International Speciality Polymers and Resins Limited

Sera Saheb Abed-Ali

Michael Stephen Chisholm

David McDonald

David Mcdonald

Ian Robinson

Robinson Ian

Michael Chisholm

A hardenable multi-part acrylic composition having at least two parts that react upon mixing to form a cement, such as bone cement, which hardens to a solid is described that includes storage stable liquid first and second parts, and optionally, further liquid parts. The parts react upon mixing to form a cement that hardens to a solid. The composition includes an acrylic monomer component and an initiator component in an amount effective to polymerize the acrylic monomer component when mixed and/or activated with it. The liquid first part comprises an aqueous dispersion of acrylic polymer particles and acrylic polymer beads. The polymer beads are at an equilibrium water content with the aqueous phase of the dispersion that generally has a viscosity between 10 and 10,000 centipoise. A twin barreled syringe, caulking gun or other cement mixing and delivery device and a method of producing the composition are also described.

Hardenable multi-part acrylic composition

A hardenable multi-part acrylic composition comprises a solid first part and a storage stable liquid second part and optionally, further solid and/or liquid parts, the parts being operable to form a cement which hardens to a solid mass upon mixing. The composition further comprises an acrylic monomer component in the second part, an initiator component, a first sub-population of acrylic polymer particles in the first and/or further parts, a second sub-population of acrylic polymer particles in the first and/or further parts and optionally, one or more further sub-population(s) of acrylic polymer particles, and a radiopacifying filler. The initiator component amount is effective to polymerize the acrylic monomer component upon mixing. At least some of the radiopacifying filler is encapsulated within and/or adsorbed on the first sub-population of acrylic polymer particles and the second sub-population of acrylic polymer particles has a lower average particle size than the first.

The invention relates to a hardenable multi-part liquid acrylic composition. The composition comprises a storage stable liquid first part, a storage stable liquid second part and optionally, a third or further liquid parts. The parts are operable to form a cement which hardens to a solid upon mixing of the parts together. The composition comprises an acrylic monomer component, an initiator component, acrylic polymer particles and a radiopacifying filler. The initiator component is present in an amount of effective to polymerize the acrylic monomer component upon being mixed and/or activated therewith. At least some of the radiopacifying filler is encapsulated within and/or adsorbed on the acrylic polymer particles in a liquid part. The invention extends to an at least twin barreled syringe or caulking gun accommodating the multi-part composition, a method of producing the multi-part composition, a composition for use as bone cement composition or in dental repairs, a liquid composition comprising a first sub-population of emulsion or non-emulsion polymerized acrylic polymer particles and radiopacifying filler encapsulated and/or adsorbed in the first sub-population of acrylic polymer particles and bone cement compositions or dental compositions.

A hardenable two part acrylic composition is described for the treatment of human or animal bone is described. The composition comprises a storage stable liquid first part and a storage stable liquid second part which react with each other upon mixing to form a cement which hardens. The composition further comprises an acrylic monomer component and an initiator component in an amount effective to polymerize the monomer component. The monomer component and the initiator component are generally located in separate parts of the two part composition so that the monomer component is storage stable. The liquid first part comprises emulsion polymerized acrylic polymer particles in a liquid carrier. A method of producing a hardenable two part acrylic composition is also described. The composition is particularly useful in a syringe or caulking gun having at least two barrels.

Hardenable two part acrylic composition

A hardenable two part acrylic composition, a polymer component of the two part hardenable composition and a method of producing a polymer component of the two part composition are disclosed. The hardenable two part acrylic composition includes an acrylic polymer composition first part and an acrylic monomer composition second part. The acrylic polymer composition first part includes a first type of acrylic polymer particles wherein each first type of acrylic polymer particle is formed of a network of coalesced emulsion polymerized acrylic microparticles or is macroporous. The acrylic polymer composition may include emulsion polymerised acrylic polymer particles of particle size between 10 and 2000 nm and includes the use of acrylic polymer particles formed of a network of coalesced emulsion polymerized acrylic microparticles as a dough time reduction agent in a hardenable two part acrylic composition.

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Newton Aycliffe, United Kingdom

Sera Saheb Abed-Ali