Orion Corporation

Hormos Medical Corporation

Oy Juvantia Pharma Ltd.

Seppo Parhi

Arto J Karjalainen

Jarmo J Pystynen

Heimo O Haikala

Arja Marketta Kalapudas

Pentti T Nore

Jouko Levijoki

Eija Tiainen

Piero Pollesello

Juha Kaivola

Carola Tilgmann

Jukka Tenhunen

Päivi Juujärvi

Helena Korte

Petri Kaheinen

Kari L&ouml;nnberg

Jaana Karjalainen

Mervi Puska

Petri Hukka

Ismo Ulmanen

A method of isolating detomidine (I) hydrochloride as a crystalline salt is provided. The method comprises hydrogenating in the presence of a catalyst of compound of formula (II) in aqueous solution comprising hydrochloric acid, concentrating the solution by distillation, optionally adding hydrochloric acid to the concentrated solution, cooling the concentrated solution and recovering the crystallized detomidine hydrochloride. The product can be recovered directly from aqueous solution with 

Detomidine hydrochloride crystallization method

A method of isolating atipamezole hydrocloride as a crystalline salt is provided.

Atipamezole hydrochloride crystallization method

The invention relates to a process for preparing substituted imidazole derivatives of formula (I) and acid addition salts thereof in which formula Y is &#x2014;CH&#x2014; or &#x2014;CO&#x2014;, Ris H, halo or hydroxy, Ris H or halo and Ris H or lower alkyl, starting from a compound of formula (II) wherein Y, R, Rand Rare as defined above. The invention also relates to intermediates and their preparation.

Process for preparing substituted imidazole derivatives and intermediates used in the process

A method for the production of hydroxymatairesinol or a hydroxymatairesinol complex from wood, including the steps of a) extracting finely divided wood material with a polar solvent, b) optionally concentrating the extract by separating at least part of the solvent, c) adding to the extract an agent able to form a complex with hydroxymatairesinol, d) precipitating the hydroxymatairesinol complex, and optionally e) releasing the hydroxymatairesinol from the complex.

Method for the production of a phenolic substance from wood

A method for obtaining direct dilatation of the coronary arteries by administering a therapeutically effective amount of a phospholamban inhibitor is described. Compounds which are effective in relieving the inhibitory effects of phospholamban on cardiac sarcoplasmic reticulum Ca,-ATPase are also described.

Phospholamban inhibitors and a method for increasing coronary flow

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Oulu, Finland

Seppo Parhi