Ontogen Corporation

Sepehar Sarshar

Chengzhi Zhang

Adnan M Mjalli

There are disclosed methods useful for the inhibition of inducible nitric oxide synthase by the adminstration of a compound of the formula I:. when R.sub.2 is H then R.sub.1 is selected from the group consisting of:

Naphthalenedione nitric oxide synthase (NOS) inhibitors

There are disclosed methods useful for the inhibition of inducible nitric oxide synthase by the adminstration of a compound of the Formula I: ##STR1## to a patient in need of such inhibition such as hypotension, inflammation, autoimmune diseases and septic shock and the like.

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Cardiff, CA, United States of America

Sepehar Sarshar