Mogam Biotechnology Research Institute

Yonsei University

The Green Cross Corporation

Mogam Biotechnology Institute

Seongtae Yun

Kyuhyun Lee

Eui-Cheol Jo

Daekyung Koh

Hyeon Bum Lee

Hong-Kyu Lee

Chae-Ok Yun

Mee Sook Oh

Heechun Kwak

Sumin Lee

Mihee Hwang

Jung-Seob Kim

Provided is an expression vector having an improved ability to express a gene. Also provided are cells transformed by the expression vector and a method for mass-producing a target protein by using the cells. The expression vector contains a simian virus 40 promoter, a scaffold attachment region or matrix attachment region element, and a chimeric intron. The vector shows an improved ability to express a gene, and thus, can attain a significantly increased expression of a heterogeneous gene.

Expression vector for expressing heterogeneous gene

Novel hexon isolated from simian adenovirus serotype 19 encoded in the polynucleotide defined as SEQ ID NO: 3, hepervariable region thereof, chimeric adenovirus comprising the same, and therapeutic use thereof provides a solution to the problem of safety and effective systemic treatment for developing gene therapeutic agents using adenovirus.

Hexon isolated from simian adenovirus serotype 19, hypervariable region thereof and chimeric adenovirus using the same

Provided are tumor-specific promoters, oncolytic virus vectors and a pharmaceutical composition comprising the virus vector. The virus vector comprising the novel tumor-specific promoter shows excellent oncolytic effects on tumor cells, and thus it is useful for treating a cancer.

Tumor specific promoter and oncolytic virus vector comprising the same

Provided is an expression vector for gene therapy having a novel combination of transcriptional regulatory elements, including a promoter, an enhancer, an intron, an untranslated region (UTR) and a locus control region (LCR). The expression vector enables sustained expression of a liver tissue-specific gene, and thus, can be effectively used for treating thrombosis, hemophilia, liver cancer, etc.

Expression vector suitable for expression of a coding sequence for gene therapy

Expression vector for gene therapy

Growing community of inventors

Yongin-si, South Korea

Seongtae Yun