Postech Academy-industry Foundation

Seonghwan Lee

Changill Ban

Yoon-Keun Kim

Weejeong Jeon

Hyung Jun Youn

Hunho Jo

Weejeong Jeong

The present invention relates to a DNA aptamer specifically binding to EN2 (Engrailed-2), a biosensor for diagnosing prostate cancer having the same, and a method of diagnosing prostate cancer. A strong binding force and excellent specificity of the DNA aptamer of the present invention and the biosensor using the same with respect to EN2 proteins were identified. A detection specificity problem of a prostate-specific antigen (PSA) test used for prostate cancer diagnosis of the related art was addressed. Therefore, the present invention is expected to be beneficially used for early diagnosis of prostate cancer more effectively and increase diagnostic accuracy.

DNA aptamer specifically binding to EN2 (engrailed-2) and use thereof

Disclosed herein are a DNA aptamer specifically binding to pLDH (Lactate Dehydrogenase), a composition for the diagnosis of malaria, comprising the same, and a diagnostic kit for malaria using the same. Superior in specificity and stability to antibodies which are conventionally used to diagnose malaria, the DNA aptamers specifically binding to pLDH (Lactate Dehydrogenase) in accordance with the present invention can be developed into biosensors which determine pLDH levels with high sensitivity and accuracy, greatly contributing to the diagnostic accuracy of malaria.

DNA aptamer specifically binding to pLDH (plasmodium lactate dehydrogenase)

Growing community of inventors

Gyeonggi-do, South Korea

Seonghwan Lee