Crystalgenomics, Inc.

Yuyu, Inc.

Daegu-Gyeongbuk Medical Innovation Foundation

Pimedbio, Inc.

Seonggu Ro

So Young Kim

Joong Myung Cho

Jeong Eun Na

Hyun Ju Cha

Sool Ki Kwon

Yong Rae Hong

Cheol Min Kim

Seung Chul Lee

Ye Ri Han

Dongkyu Shin

Seungyeon Lee

Im Sook Min

Dong Kyu Shin

Tae Gyu Lee

Jin Hwan Kim

Dong Gyu Shin

Jae-yeon Park

Doohyun Lee

Heejin Lee

Young Ho Jeon

Nam Hui Kim

Sang Hyun Min

Eunmi Hong

Young Lan Hyun

Chun Young Im

Jae-Yeon Park

Young-Lan Hyun

Hui-Jeon Jeon

Bae Jun Oh

Tae Ryong Kim

Jun Woo Kim

Byung-Ha Kim

Kyung Joo Lee

Sik Ii Ahn

Eun Bi Ko

Minsoo Song

Chang Hoon Seo

Jeong-Eun Park

Ji Hoon Yu

Young-Hoon Park

Sik Il Ahn

Dong Kyu Choi

Ga Young Park

The present invention provides a compound selected from the group consisting of a compound of formula (I), pharmaceutically acceptable salts, esters, prodrugs, hydrates, solvates and isomers thereof; a use of the compound for the treatment, relief or prevention of diseases caused by absormal or uncontrolled activation of protein kinase, and a use of the compound for the manufacture of a medicament for the treatment, relief or prevention of the diseases; a pharmaceutical composition comprising the compound as an active ingredient; and a method for the treatment, relief or prevention of the diseases using the compound. The inventive compound is useful for the treatment, relief or prevention of diseases caused by abnormal or uncontrolled activation of protein kinase.

2,3-dihydro-isoindole-1-one derivative as BTK kinase suppressant, and pharmaceutical composition including same

The present invention provides a compound selected from the group consisting of a compound of formula (I), pharmaceutically acceptable salts, esters, prodrugs, hydrates, solvates and isomers thereof; a use of the compound for the treatment, relief or prevention of diseases caused by abnormal or uncontrolled activation of protein kinase, and a use of the compound for the manufacture of a medicament for the treatment, relief or prevention of the diseases; a pharmaceutical composition comprising the compound as an active ingredient; and a method for the treatment, relief or prevention of the diseases using the compound. The inventive compound is useful for the treatment, relief or prevention of diseases caused by abnormal or uncontrolled activation of protein kinase.

The present invention relates to a pharmaceutical composition including (i) as a major ingredient, a novel 5-{4-(Aminosulfonyl)phenyl}-2,2-dimethyl-4-(3-fluorophenyl)-3(2H)-furanone compound (Formula 1) or a pharmaceutically acceptable salt thereof, which has a crystalline form A or G, or a mixed form thereof and has a 50% volume particle diameter (d) of 3 &#x3bc;m to 9 &#x3bc;m and a 90% volume particle diameter (d) of 10 &#x3bc;m to 50 &#x3bc;m, (ii) a pharmaceutically acceptable diluent, and (iii) a pharmaceutically acceptable lubricant. The pharmaceutical composition of the present invention has the advantages of good stability, high dissolution rate, improved content uniformity, and excellent pharmacokinetic properties. Due to these advantages, as a non-steroidal anti-inflammatory drug, the pharmaceutical composition of the present invention may be effective in treating inflammation or pain.

Oral pharmacological composition including 5-{4-(amino sulfonyl)phenyl}-2,2-dimethyl-4-(3-fluorophenyl)-3(2H)-furanone having crystalline structure with excellent stability

2,3-dihydro-isoindole-1-on derivative as BTK kinase suppressant, and pharmaceutical composition including same

A compound which is effective for inhibiting Fab I, and a method for treating a bacterial infection.

Fab I inhibitor and process for preparing same

Novel compounds having hydroxybenzoimidazole carboxylic amide are useful for inhibiting glycogen synthase kinase 3&#x3b2;(GSK-3&#x3b2;).

Glycogen synthase kinase 3&#x3b2; inhibitor, composition and process for the preparation thereof

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Seonggu Ro